Component
Sustained alanine aminotransferase reduction
Sustained alanine aminotransferase reduction. Read linked claims for the population, experiment and limits.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
TONIC did not meet its primary sustained-ALT endpoint with vitamin E: 15/58 children (26%) responded versus 10/58 (17%) with placebo (P=0.26).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- TONIC randomized double-blind trial; 173 children aged 8–17 with biopsy-confirmed NAFLD
- exposure
- RRR-alpha-tocopherol 400 IU twice daily for 96 weeks; E and placebo groups n=58 each.
- limitations
- Primary sustained-ALT endpoint and secondary histology must remain distinct. Not evidence for every child, every liver condition or long-term clinical outcome.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- The pediatric trial did not achieve its primary liver-enzyme outcome.
- primary_references
- [e-clin-tonic2011] Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/21521847/ DOI: 10.1001/jama.2011.520
- tissue_or_cell_type
- Liver enzymes and biopsy
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1427–1438
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · TONIC randomized double-blind trial; 173 children aged 8–17 with biopsy-confirmed NAFLD · source_derived_draft · unverified_draft
### e-clin-tonic-alt TONIC did not meet its primary sustained-ALT endpoint with vitamin E: 15/58 children (26%) responded versus 10/58 (17%) with placebo (P=0.26). Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The pediatric trial did not achieve its primary liver-enzyme outcome. organism: Homo sapiens tissue_or_cell_type: Liver enzymes and biopsy experimental_model: TONIC randomized double-blind trial; 173 children aged 8–17 with biopsy-confirmed NAFLD limitations: Primary sustained-ALT endpoint and secondary histology must remain distinct. Not evidence for every child, every liver condition or long-term clinical outcome. exposure: RRR-alpha-tocopherol 400 IU twice daily for 96 weeks; E and placebo groups n=58 each. cross_nutrient: false [e-clin-tonic2011] Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/21521847/ DOI: 10.1001/jama.2011.520
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.