Component
STRA6-mediated retinol uptake
Cellular acquisition of retinol from extracellular holo-RBP4.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Coexpression of LRAT enhanced STRA6-mediated retinol uptake by coupling transport to ester storage.
Experimental context and source evidence
- evidence_location
- Figure 1
- experimental_model
- Transfected-cell radioretinol uptake and real-time retinol-release assays.
- exposure
- STRA6 with or without LRAT; radiolabeled holo-RBP uptake.
- limitations
- No single intracellular protein was absolutely required for STRA6 activity. Cell-line species were not resolved in the retrieved abstract/figure evidence; no species-specific extension is asserted.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mammalian transfected cells
- outcome
- Coexpression of LRAT enhanced STRA6-mediated retinol uptake by coupling transport to ester storage.
- plain_language
- Retinol esterification helps keep inward uptake moving.
- primary_references
- [va-kawaguchi-2011] Receptor-mediated cellular uptake mechanism that couples to intracellular storage (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3199320/ DOI: 10.1021/cb200178w
- tissue_or_cell_type
- Plasma membrane and intracellular retinoid compartment
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 459–471
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transfected-cell radioretinol uptake and real-time retinol-release assays. · source_derived_draft · unverified_draft
### va-lrat-couples-stra6 Coexpression of LRAT enhanced STRA6-mediated retinol uptake by coupling transport to ester storage. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Retinol esterification helps keep inward uptake moving. organism: Mammalian transfected cells tissue_or_cell_type: Plasma membrane and intracellular retinoid compartment experimental_model: Transfected-cell radioretinol uptake and real-time retinol-release assays. limitations: No single intracellular protein was absolutely required for STRA6 activity. Cell-line species were not resolved in the retrieved abstract/figure evidence; no species-specific extension is asserted. exposure: STRA6 with or without LRAT; radiolabeled holo-RBP uptake. outcome: Coexpression of LRAT enhanced STRA6-mediated retinol uptake by coupling transport to ester storage. evidence_location: Figure 1 [va-kawaguchi-2011] Receptor-mediated cellular uptake mechanism that couples to intracellular storage (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3199320/ DOI: 10.1021/cb200178w
Complete structured claim and evidenceCellular RBP1 enhanced STRA6-mediated uptake of RBP-bound retinol.
Experimental context and source evidence
- evidence_location
- Figure 1
- experimental_model
- Transfected-cell radioretinol uptake and real-time retinol-release assays.
- exposure
- STRA6 plus CRBP-I compared with STRA6 alone.
- limitations
- Coupling is supported, but absolute RBP1 dependence is not. Cell-line species were not resolved in the retrieved abstract/figure evidence; no species-specific extension is asserted.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mammalian transfected cells
- outcome
- Cellular RBP1 enhanced STRA6-mediated uptake of RBP-bound retinol.
- plain_language
- An intracellular retinol-binding protein helps retain delivered vitamin A.
- primary_references
- [va-kawaguchi-2011] Receptor-mediated cellular uptake mechanism that couples to intracellular storage (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3199320/ DOI: 10.1021/cb200178w
- tissue_or_cell_type
- Plasma membrane and cytoplasm
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 473–485
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transfected-cell radioretinol uptake and real-time retinol-release assays. · source_derived_draft · unverified_draft
### va-rbp1-couples-stra6 Cellular RBP1 enhanced STRA6-mediated uptake of RBP-bound retinol. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: An intracellular retinol-binding protein helps retain delivered vitamin A. organism: Mammalian transfected cells tissue_or_cell_type: Plasma membrane and cytoplasm experimental_model: Transfected-cell radioretinol uptake and real-time retinol-release assays. limitations: Coupling is supported, but absolute RBP1 dependence is not. Cell-line species were not resolved in the retrieved abstract/figure evidence; no species-specific extension is asserted. exposure: STRA6 plus CRBP-I compared with STRA6 alone. outcome: Cellular RBP1 enhanced STRA6-mediated uptake of RBP-bound retinol. evidence_location: Figure 1 [va-kawaguchi-2011] Receptor-mediated cellular uptake mechanism that couples to intracellular storage (2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3199320/ DOI: 10.1021/cb200178w
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.