Component
Human OATP1C1 / SLCO1C1
Human OATP1C1 / SLCO1C1
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The 2.3-angstrom human OATP1C1 structure places T4 in a side pocket where K376, N399 and S562 coordinate the outer-ring hydroxyl group.
Experimental context and source evidence
- evidence_locator
- Results: Structure and mechanism of T4 transport by OATP1C1; Figure 3
- evidence_spans
- [{"source_document": "artifacts/iodine-metabolism-sources/40680733.txt", "locator": "Results: Structure and mechanism of T4 transport by OATP1C1; Figure 3", "start_char": 30218, "end_char": 32418}]
- experimental_model
- Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays
- exposure
- T4-bound cryo-EM structure; complementary radiolabeled-T4 uptake experiments.
- limitations
- Static structure; possible lateral entry and lipid cotransport are not established by this record.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Human
- plain_language
- OATP1C1 has a defined binding pocket for the thyroid hormone precursor T4.
- primary_references
- [i-met-40680733] Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. (2025). https://pubmed.ncbi.nlm.nih.gov/40680733/ DOI: 10.1016/j.cell.2025.06.032
- tissue_or_cell_type
- Purified human membrane transporter
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 954–966
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays · source_derived_draft · unverified_draft
### i-met-oatp1c1-t4-binding The 2.3-angstrom human OATP1C1 structure places T4 in a side pocket where K376, N399 and S562 coordinate the outer-ring hydroxyl group. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: OATP1C1 has a defined binding pocket for the thyroid hormone precursor T4. organism: Human tissue_or_cell_type: Purified human membrane transporter experimental_model: Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays limitations: Static structure; possible lateral entry and lipid cotransport are not established by this record. exposure: T4-bound cryo-EM structure; complementary radiolabeled-T4 uptake experiments. evidence_locator: Results: Structure and mechanism of T4 transport by OATP1C1; Figure 3 evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/40680733.txt", "locator": "Results: Structure and mechanism of T4 transport by OATP1C1; Figure 3", "start_char": 30218, "end_char": 32418}] [i-met-40680733] Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. (2025). https://pubmed.ncbi.nlm.nih.gov/40680733/ DOI: 10.1016/j.cell.2025.06.032
Complete structured claim and evidence
Where it participates (unsigned role)
Human OATP1C1 K376A abolished measured radiolabeled-T4 uptake without lowering cell-surface expression relative to wild type.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_locator
- Figure 3E and Supplemental Figure S3B
- evidence_spans
- [{"source_document": "artifacts/iodine-metabolism-sources/40680733.txt", "locator": "Figure 3E and Supplemental Figure S3B", "start_char": 30544, "end_char": 32244}]
- experimental_model
- Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays
- exposure
- K376A versus wild type; 0.5 nM 125I-T4 for 30 minutes at 37 C in DMEM with 0.1% BSA; three independent uptake experiments.
- limitations
- Engineered alanine mutant; no in-vivo dose or dietary threshold inferred.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Human
- plain_language
- This pocket residue affects transport function even when the carrier reaches the membrane.
- primary_references
- [i-met-40680733] Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. (2025). https://pubmed.ncbi.nlm.nih.gov/40680733/ DOI: 10.1016/j.cell.2025.06.032
- tissue_or_cell_type
- Stable HEK293 cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 968–980
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays · source_derived_draft · unverified_draft
### i-met-oatp-k376a Human OATP1C1 K376A abolished measured radiolabeled-T4 uptake without lowering cell-surface expression relative to wild type. Condition category: machinery_impairment nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This pocket residue affects transport function even when the carrier reaches the membrane. organism: Human tissue_or_cell_type: Stable HEK293 cells experimental_model: Human OATP1C1 cryo-EM and stable HEK293 wild-type/mutant uptake assays limitations: Engineered alanine mutant; no in-vivo dose or dietary threshold inferred. exposure: K376A versus wild type; 0.5 nM 125I-T4 for 30 minutes at 37 C in DMEM with 0.1% BSA; three independent uptake experiments. evidence_locator: Figure 3E and Supplemental Figure S3B evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/40680733.txt", "locator": "Figure 3E and Supplemental Figure S3B", "start_char": 30544, "end_char": 32244}] [i-met-40680733] Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. (2025). https://pubmed.ncbi.nlm.nih.gov/40680733/ DOI: 10.1016/j.cell.2025.06.032
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.