Component
Human sodium/glucose cotransporter 2 / SGLT2
Species, preparation, dose and limitations are retained on linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Human SGLT2 expressed in Xenopus oocytes transported glucose with a 1:1 sodium-to-glucose ratio and was phlorizin-sensitive.
Experimental context and source evidence
- dose
- Glucose or alpha-methylglucose with sodium and phlorizin
- duration
- Acute transport assay
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Human SGLT2 expressed in Xenopus oocytes
- limitations
- Oocyte transport identifies function but does not define human oral phlorizin exposure or renal selectivity in vivo.
- nutrient_topic
- Phlorizin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Phlorizin
- organism
- Human SGLT2 expressed in Xenopus oocytes
- plain_language
- Human SGLT2 expressed in Xenopus oocytes transported glucose with a 1:1 sodium-to-glucose ratio and was phlorizin-sensitive.
- primary_references
- The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. (1994). https://pubmed.ncbi.nlm.nih.gov/8282810/ DOI: 10.1172/JCI116972
- route
- In vitro
- tissue
- Radiotracer uptake and voltage-clamp current
Phlorizin: mechanism of action and interactions (2026-09-20) · lines 11–20
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human SGLT2 expressed in Xenopus oocytes · source_derived_draft · unverified_draft
## phlorizin-human-sglt2-identification Human SGLT2 expressed in Xenopus oocytes transported glucose with a 1:1 sodium-to-glucose ratio and was phlorizin-sensitive. Model/species: Human SGLT2 expressed in Xenopus oocytes Tissue/system: Radiotracer uptake and voltage-clamp current Exposure: Glucose or alpha-methylglucose with sodium and phlorizin Route: In vitro Duration: Acute transport assay Limits: Oocyte transport identifies function but does not define human oral phlorizin exposure or renal selectivity in vivo. Primary reference: The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. (1994). https://pubmed.ncbi.nlm.nih.gov/8282810/ DOI: 10.1172/JCI116972 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidencePhlorizin inhibited human SGLT2 more strongly than SGLT1 in HEK293T electrophysiology, with reported Ki values of 11 and 140 nM, respectively.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Phlorizin concentration-response
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- HEK293T cells expressing human SGLT2 or SGLT1
- limitations
- The indexed article has an erratum notice; the exact correction was not recovered in this curation and the numerical values require rechecking before quantitative reuse.
- nutrient_topic
- Phlorizin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Phlorizin
- organism
- HEK293T cells expressing human SGLT2 or SGLT1
- plain_language
- Phlorizin inhibited human SGLT2 more strongly than SGLT1 in HEK293T electrophysiology, with reported Ki values of 11 and 140 nM, respectively.
- primary_references
- Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. (2011). https://pubmed.ncbi.nlm.nih.gov/20980548/ DOI: 10.1152/ajpcell.00388.2010
- route
- In vitro
- tissue
- Whole-cell sodium/glucose cotransport current
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Phlorizin: mechanism of action and interactions (2026-09-20) · lines 22–31
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · HEK293T cells expressing human SGLT2 or SGLT1 · source_derived_draft · unverified_draft
## phlorizin-sglt1-sglt2-affinity Phlorizin inhibited human SGLT2 more strongly than SGLT1 in HEK293T electrophysiology, with reported Ki values of 11 and 140 nM, respectively. Model/species: HEK293T cells expressing human SGLT2 or SGLT1 Tissue/system: Whole-cell sodium/glucose cotransport current Exposure: Phlorizin concentration-response Route: In vitro Duration: Acute Limits: The indexed article has an erratum notice; the exact correction was not recovered in this curation and the numerical values require rechecking before quantitative reuse. Primary reference: Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. (2011). https://pubmed.ncbi.nlm.nih.gov/20980548/ DOI: 10.1152/ajpcell.00388.2010 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.