Component
Human mitoferrin-1 / SLC25A37
Human mitoferrin-1 / SLC25A37. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A39-mediated GSH homeostasis and A37-mediated iron uptake jointly supported OXPHOS in the genetic-interaction system.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/35513392.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "000d49d8bad7e173d95c214f6cb2bf2ea84b9e4af231687687d1aa703cdeaff7", "start_char": 0, "end_char": 1457, "text_sha256": "000d49d8bad7e173d95c214f6cb2bf2ea84b9e4af231687687d1aa703cdeaff7"}
- experimental_model
- Paired CRISPR screen and mitochondrial transport assays
- exposure
- 2016 single/pair perturbations across four metabolic states
- limitations
- Genetic buffering depends on metabolic conditions; it is not evidence that iron supplementation corrects low GSH.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human experimental cells
- plain_language
- Iron delivery and glutathione delivery met at mitochondrial energy production.
- primary_references
- [glutathione-p35513392] Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. (2022). https://pubmed.ncbi.nlm.nih.gov/35513392/ DOI: 10.1038/s41467-022-30126-9
- tissue_or_cell_type
- Mitochondrial transport and respiration
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 528–539
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired CRISPR screen and mitochondrial transport assays · source_derived_draft · unverified_draft
### glutathione-a39-iron-oxphos A39-mediated GSH homeostasis and A37-mediated iron uptake jointly supported OXPHOS in the genetic-interaction system. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron delivery and glutathione delivery met at mitochondrial energy production. organism: Human experimental cells tissue_or_cell_type: Mitochondrial transport and respiration experimental_model: Paired CRISPR screen and mitochondrial transport assays limitations: Genetic buffering depends on metabolic conditions; it is not evidence that iron supplementation corrects low GSH. exposure: 2016 single/pair perturbations across four metabolic states evidence_span: {"source_cache": "artifacts/glutathione-research/35513392.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "000d49d8bad7e173d95c214f6cb2bf2ea84b9e4af231687687d1aa703cdeaff7", "start_char": 0, "end_char": 1457, "text_sha256": "000d49d8bad7e173d95c214f6cb2bf2ea84b9e4af231687687d1aa703cdeaff7"} [glutathione-p35513392] Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. (2022). https://pubmed.ncbi.nlm.nih.gov/35513392/ DOI: 10.1038/s41467-022-30126-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.