Component
Human neutral amino acid exchanger ASCT2 / SLC1A5
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
L-threonine inhibited radiolabeled L-serine uptake in HEK cells expressing human ASCT2, with an IC50 of 228 ± 83 micromolar.
Experimental context and source evidence
- evidence_access
- Primary full-text Table 5, publisher PDF
- experimental_model
- Table 5: three observations per transporter; heterologous human-transporter HEK cell assays.
- limitations
- An inhibition concentration in culture is not a dietary threshold or proof of reduced brain serine.
- nutrient_topic
- L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Threonine
- plain_language
- Threonine can compete with serine in a defined transporter assay.
- primary_references
- D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27272177/ · DOI 10.1371/journal.pone.0156551
L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19) · lines 34–40
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Table 5: three observations per transporter; heterologous human-transporter HEK cell assays. · source_derived_draft · unverified_draft
## l-threonine-serine-competition-slc1a5 Threonine can compete with serine in a defined transporter assay. L-threonine inhibited radiolabeled L-serine uptake in HEK cells expressing human ASCT2, with an IC50 of 228 ± 83 micromolar. Model: Table 5: three observations per transporter; heterologous human-transporter HEK cell assays. Limitations: An inhibition concentration in culture is not a dietary threshold or proof of reduced brain serine. Evidence access: Primary full-text Table 5, publisher PDF D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27272177/ · DOI 10.1371/journal.pone.0156551
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.