Component
Human MCT8 D424N (D498N in long isoform)
Human MCT8 D424N (D498N in long isoform)
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human MCT8 D424N retained measurable T4 binding but had strongly impaired cellular T4 transport, showing that binding alone does not establish transport competence.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_locator
- Figure 3; Figure 5 caption and Results: MCT8 pathogenic mutant
- evidence_spans
- [{"source_document": "artifacts/iodine-metabolism-sources/40368961.txt", "locator": "Figure 3; Figure 5 caption and Results: MCT8 pathogenic mutant", "start_char": 16912, "end_char": 18212}]
- experimental_model
- Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays
- exposure
- Patient-derived D424N short isoform, equivalent to D498N long isoform; wild-type comparator.
- limitations
- The proposed conformational explanation is structural interpretation; no dietary intervention.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Human
- plain_language
- A transporter may still bind hormone while failing to deliver it into cells.
- primary_references
- [i-met-40368961] Molecular mechanism of thyroxine transport by monocarboxylate transporters. (2025). https://pubmed.ncbi.nlm.nih.gov/40368961/ DOI: 10.1038/s41467-025-59751-w
- tissue_or_cell_type
- Purified mutant and HeLa cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 940–952
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays · source_derived_draft · unverified_draft
### i-met-mct8-d424n-binding-transport Human MCT8 D424N retained measurable T4 binding but had strongly impaired cellular T4 transport, showing that binding alone does not establish transport competence. Condition category: machinery_impairment nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter may still bind hormone while failing to deliver it into cells. organism: Human tissue_or_cell_type: Purified mutant and HeLa cells experimental_model: Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays limitations: The proposed conformational explanation is structural interpretation; no dietary intervention. exposure: Patient-derived D424N short isoform, equivalent to D498N long isoform; wild-type comparator. evidence_locator: Figure 3; Figure 5 caption and Results: MCT8 pathogenic mutant evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/40368961.txt", "locator": "Figure 3; Figure 5 caption and Results: MCT8 pathogenic mutant", "start_char": 16912, "end_char": 18212}] [i-met-40368961] Molecular mechanism of thyroxine transport by monocarboxylate transporters. (2025). https://pubmed.ncbi.nlm.nih.gov/40368961/ DOI: 10.1038/s41467-025-59751-w
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.