Component
Silychristin
Silychristin
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Silychristin inhibited human MCT8-mediated T4 uptake in transfected HeLa cells; structural and binding experiments support trapping an outward-facing transporter state.
Experimental context and source evidence
- evidence_locator
- Figures 1a-b and 4; Results: inhibitor mechanism
- evidence_spans
- [{"source_document": "artifacts/iodine-metabolism-sources/40368961.txt", "locator": "Figures 1a-b and 4; Results: inhibitor mechanism", "start_char": 17453, "end_char": 22253}]
- experimental_model
- Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays
- exposure
- Cell assays used 10 micromolar T4 with or without 10 micromolar silychristin.
- limitations
- Drug-compound experiment; does not establish dietary milk-thistle effects or an iodine-supplement interaction at usual exposure.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Human
- plain_language
- An experimental inhibitor can block hormone passage through MCT8.
- primary_references
- [i-met-40368961] Molecular mechanism of thyroxine transport by monocarboxylate transporters. (2025). https://pubmed.ncbi.nlm.nih.gov/40368961/ DOI: 10.1038/s41467-025-59751-w
- tissue_or_cell_type
- HeLa cells and purified MCT8
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 926–938
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays · source_derived_draft · unverified_draft
### i-met-silychristin-mct8 Silychristin inhibited human MCT8-mediated T4 uptake in transfected HeLa cells; structural and binding experiments support trapping an outward-facing transporter state. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: An experimental inhibitor can block hormone passage through MCT8. organism: Human tissue_or_cell_type: HeLa cells and purified MCT8 experimental_model: Purified human MCT8 structures and microscale thermophoresis; transfected HeLa transport assays limitations: Drug-compound experiment; does not establish dietary milk-thistle effects or an iodine-supplement interaction at usual exposure. exposure: Cell assays used 10 micromolar T4 with or without 10 micromolar silychristin. evidence_locator: Figures 1a-b and 4; Results: inhibitor mechanism evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/40368961.txt", "locator": "Figures 1a-b and 4; Results: inhibitor mechanism", "start_char": 17453, "end_char": 22253}] [i-met-40368961] Molecular mechanism of thyroxine transport by monocarboxylate transporters. (2025). https://pubmed.ncbi.nlm.nih.gov/40368961/ DOI: 10.1038/s41467-025-59751-w
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.