Component
Organ outcomes during septic shock
Independent biological entity. Read linked claims for experimental scope and context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
TRPSS did not find a statistically significant difference in its primary creatinine trajectory endpoint; the 72-hour estimate was -0.57 mg/dL, 95% CI -1.18 to 0.04.
Experimental context and source evidence
- experimental_model
- 88 treated patients with septic shock.
- exposure
- Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.
- limitations
- ICU-free days favored thiamine as a secondary outcome; kidney replacement, severe AKI and mortality differences were not significant.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- The renal-protection trial left an uncertain estimate rather than proving benefit.
- primary_references
- [b1-trpss2023] Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial (2023). https://pubmed.ncbi.nlm.nih.gov/37364280/ DOI: 10.1164/rccm.202301-0034oc
- tissue_or_cell_type
- Serum/clinical kidney endpoints
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1660–1670
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 88 treated patients with septic shock. · source_derived_draft · unverified_draft
### b1-trpss-creatinine-null TRPSS did not find a statistically significant difference in its primary creatinine trajectory endpoint; the 72-hour estimate was -0.57 mg/dL, 95% CI -1.18 to 0.04. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The renal-protection trial left an uncertain estimate rather than proving benefit. organism: Homo sapiens tissue_or_cell_type: Serum/clinical kidney endpoints experimental_model: 88 treated patients with septic shock. limitations: ICU-free days favored thiamine as a secondary outcome; kidney replacement, severe AKI and mortality differences were not significant. exposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence. [b1-trpss2023] Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial (2023). https://pubmed.ncbi.nlm.nih.gov/37364280/ DOI: 10.1164/rccm.202301-0034oc
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.