Sepsis mortality at day 28

What acts on it

1. Day-28 mortality was 25/84 (29.8%) with C versus 38/82 (46.3%) with placebo (P=0.03), in an exploratory analysis without adjustment for multiple comparisons.

   L-Ascorbic acid → Sepsis mortality at day 28 source_derived_draftungraded
   Experimental context and source evidence

   experimental_model

   CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).

   exposure

   IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo.

   limitations

   One of 46 secondary outcomes; 43 were nonsignificant. Different eligibility and endpoint hierarchy from LOVIT. The signal is hypothesis-generating, and no cellular mediator was proven.

   nutrient_topic

   Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C

   organism

   Homo sapiens

   plain_language

   This smaller trial reported a possible survival benefit, although its main endpoints were negative.

   primary_references

   [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825

   tissue_or_cell_type

   Human blood or whole-person endpoints

   Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1755–1765

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). · source_derived_draft · unverified_draft

   ### c-citris-exploratory-mortality-signal Day-28 mortality was 25/84 (29.8%) with C versus 38/82 (46.3%) with placebo (P=0.03), in an exploratory analysis without adjustment for multiple comparisons. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: This smaller trial reported a possible survival benefit, although its main endpoints were negative. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). limitations: One of 46 secondary outcomes; 43 were nonsignificant. Different eligibility and endpoint hierarchy from LOVIT. The signal is hypothesis-generating, and no cellular mediator was proven. exposure: IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo. [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825

   Complete structured claim and evidence

2. Day-28 mortality was 35.4% versus 31.6% (RR 1.17, 95% CI 0.98–1.40), while the combined primary endpoint was significant.

   L-Ascorbic acid → Sepsis mortality at day 28 source_derived_draftungraded
   Experimental context and source evidence

   experimental_model

   LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use.

   exposure

   IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo.

   limitations

   Confidence interval includes no difference; neither a proven mortality increase alone nor evidence of identical mortality.

   nutrient_topic

   Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C

   organism

   Homo sapiens

   plain_language

   The combined endpoint and mortality alone had different statistical results.

   primary_references

   [c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644

   tissue_or_cell_type

   Human blood or whole-person endpoints

   Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1707–1717

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use. · source_derived_draft · unverified_draft

   ### c-lovit-mortality-component Day-28 mortality was 35.4% versus 31.6% (RR 1.17, 95% CI 0.98–1.40), while the combined primary endpoint was significant. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combined endpoint and mortality alone had different statistical results. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: LOVIT: multicenter placebo-controlled randomized ICU trial; 872 randomized, 863 in primary analysis, with sepsis and vasopressor use. limitations: Confidence interval includes no difference; neither a proven mortality increase alone nor evidence of identical mortality. exposure: IV vitamin C 50 mg/kg every six hours for up to 96 hours versus matched placebo. [c-lamontagne2022] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (2022). https://pubmed.ncbi.nlm.nih.gov/35704292/ DOI: 10.1056/nejmoa2200644

   Complete structured claim and evidence