Component

SepCysS

Independent entity for contextual scientific-audit claims; no universal nutritional effect implied.

1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Archaeal SepCysS converts tRNA-bound phosphoserine into Cys-tRNA; Sec is therefore not uniquely synthesized on tRNA across all life.

    SepCysS → cysteinyl-tRNA Cys source_derived_draftliterature_reviewed:direct_experimental
    Experimental context and source evidence
    cell_type
    Archaeal cells
    experimental_model
    Methanocaldococcus jannaschii enzymes and Methanococcus maripaludis genetics
    limitations
    This is not a human cysteine biosynthesis pathway.
    organism
    Methanocaldococcus jannaschii and Methanococcus maripaludis

    Selenium: literature corrections and mechanism additions · lines 1166–1176

    Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Methanocaldococcus jannaschii enzymes and Methanococcus maripaludis genetics · secondary_verified · secondary_verified

    ## archaeal-cys-trna Some archaea also make cysteine while it is attached to tRNA. Archaeal SepCysS converts tRNA-bound phosphoserine into Cys-tRNA; Sec is therefore not uniquely synthesized on tRNA across all life. Organism: Methanocaldococcus jannaschii and Methanococcus maripaludis Cell type: Archaeal cells Experimental model: Methanocaldococcus jannaschii enzymes and Methanococcus maripaludis genetics Limitations: This is not a human cysteine biosynthesis pathway. Primary reference: [RNA-Dependent Cysteine Biosynthesis in Archaea](https://pubmed.ncbi.nlm.nih.gov/15790858/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards