Component
Transport of secretory granules to the terminal web
Transport of secretory granules to the terminal web. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After 6 and 9 hours of treatment the characteristic changes in Ascaris suum intestinal cells were absence of secretory granules in the terminal web, accumulation of secretory granules in the Golgi region, formation of autophagic vacuoles in the apical cell part, and loss of glycogen, and cytochemistry revealed that the accumulated granules in the Golgi area contained glycoproteins or polysaccharides.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/1117352.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e7cf1916636fe33e5b6ce6c22d84d2550adfd392b30b1b940f4c794b3069066f", "start_char": 0, "end_char": 1554, "text_sha256": "e7cf1916636fe33e5b6ce6c22d84d2550adfd392b30b1b940f4c794b3069066f"}
- experimental_model
- Ultrastructural and cytochemical examination of Ascaris suum intestine from pigs fed medicated food
- exposure
- Mebendazole at 30 parts per million in pig feed, with parasites collected 6, 9, 15 and 24 hours after feeding began
- limitations
- The earliest mechanistic record here and still the clearest picture of the consequence. It predates the tubulin work and describes exactly what blocking microtubule-based transport would produce.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Nematode
- plain_language
- The cargo piles up where it is made and never arrives where it is needed.
- primary_references
- [mbz-p1117352] Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo. (1975). https://pubmed.ncbi.nlm.nih.gov/1117352/ DOI: 10.2307/3279120
- tissue_or_cell_type
- Ascaris suum intestine
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ultrastructural and cytochemical examination of Ascaris suum intestine from pigs fed medicated food · source_derived_draft · unverified_draft
### mbz-secretory-transport-fails After 6 and 9 hours of treatment the characteristic changes in Ascaris suum intestinal cells were absence of secretory granules in the terminal web, accumulation of secretory granules in the Golgi region, formation of autophagic vacuoles in the apical cell part, and loss of glycogen, and cytochemistry revealed that the accumulated granules in the Golgi area contained glycoproteins or polysaccharides. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: The cargo piles up where it is made and never arrives where it is needed. organism: Nematode tissue_or_cell_type: Ascaris suum intestine experimental_model: Ultrastructural and cytochemical examination of Ascaris suum intestine from pigs fed medicated food limitations: The earliest mechanistic record here and still the clearest picture of the consequence. It predates the tubulin work and describes exactly what blocking microtubule-based transport would produce. exposure: Mebendazole at 30 parts per million in pig feed, with parasites collected 6, 9, 15 and 24 hours after feeding began evidence_span: {"source_cache": "artifacts/mebendazole-research/1117352.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e7cf1916636fe33e5b6ce6c22d84d2550adfd392b30b1b940f4c794b3069066f", "start_char": 0, "end_char": 1554, "text_sha256": "e7cf1916636fe33e5b6ce6c22d84d2550adfd392b30b1b940f4c794b3069066f"} [mbz-p1117352] Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo. (1975). https://pubmed.ncbi.nlm.nih.gov/1117352/ DOI: 10.2307/3279120
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.