Component
Human cardiac sodium channel Nav1.5 / SCN5A
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Eugenol concentration-dependently inhibited human Nav1.5, favored the inactivated state, slowed recovery, and attenuated late sodium current.
Experimental context and source evidence
- dose
- Eugenol concentration-response; ouabain arrhythmia model
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- HEK cells expressing human Nav1.5; isolated guinea-pig atria
- limitations
- Channel inhibition can alter cardiac excitability; isolated atrial antiarrhythmic effects are not a human treatment result.
- nutrient_topic
- Eugenol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Eugenol
- organism
- HEK cells expressing human Nav1.5; isolated guinea-pig atria
- plain_language
- Eugenol concentration-dependently inhibited human Nav1.5, favored the inactivated state, slowed recovery, and attenuated late sodium current.
- primary_references
- Eugenol interacts with cardiac sodium channel and reduces heart excitability and arrhythmias. (2021). https://pubmed.ncbi.nlm.nih.gov/34217764/ DOI: 10.1016/j.lfs.2021.119761
- route
- In vitro and ex vivo
- tissue
- Cardiac sodium current and ex-vivo rhythm disturbance
Eugenol: mechanism of action and interactions (2026-09-20) · lines 55–64
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · HEK cells expressing human Nav1.5; isolated guinea-pig atria · source_derived_draft · unverified_draft
## eugenol-nav15 Eugenol concentration-dependently inhibited human Nav1.5, favored the inactivated state, slowed recovery, and attenuated late sodium current. Model/species: HEK cells expressing human Nav1.5; isolated guinea-pig atria Tissue/system: Cardiac sodium current and ex-vivo rhythm disturbance Exposure: Eugenol concentration-response; ouabain arrhythmia model Route: In vitro and ex vivo Duration: Acute Limits: Channel inhibition can alter cardiac excitability; isolated atrial antiarrhythmic effects are not a human treatment result. Primary reference: Eugenol interacts with cardiac sodium channel and reduces heart excitability and arrhythmias. (2021). https://pubmed.ncbi.nlm.nih.gov/34217764/ DOI: 10.1016/j.lfs.2021.119761 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.