Component

S-Sulfocysteine

S-Sulfocysteine. Species, exposure and limitations are retained in each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Combined NMDA- and AMPA-receptor blockade almost completely suppressed SSC-evoked currents, supporting SSC agonism at both receptor classes.

    S-Sulfocysteine → AMPA-type glutamate receptors source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/29106383.fulltext.txt", "locator": "Exact primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d7cfb311498ba2a88e3fc04be988dcffda740bbd1d93ada686cabf801861cf2a", "start_char": 16686, "end_char": 17024, "text_sha256": "bc275c8c18044e88885db4ff2c7ebbca4376b6e4c1b7b88b66385a33c7775b5b"}
    experimental_model
    Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice
    exposure
    SSC/sulfite exposure; receptor/calcium/calpain inhibition
    limitations
    Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Mus musculus neurons and mice; chemical reaction assays
    plain_language
    More than one excitatory receptor contributed to the electrical response.
    primary_references
    [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    tissue_or_cell_type
    Neuronal receptors, intracellular calcium and inhibitory synapses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1262–1273

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice · source_derived_draft · unverified_draft

    ### mo-ssc-ampa Combined NMDA- and AMPA-receptor blockade almost completely suppressed SSC-evoked currents, supporting SSC agonism at both receptor classes. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: More than one excitatory receptor contributed to the electrical response. organism: Mus musculus neurons and mice; chemical reaction assays tissue_or_cell_type: Neuronal receptors, intracellular calcium and inhibitory synapses experimental_model: Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice limitations: Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity. exposure: SSC/sulfite exposure; receptor/calcium/calpain inhibition evidence_span: {"source_cache": "artifacts/molybdenum-research/29106383.fulltext.txt", "locator": "Exact primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d7cfb311498ba2a88e3fc04be988dcffda740bbd1d93ada686cabf801861cf2a", "start_char": 16686, "end_char": 17024, "text_sha256": "bc275c8c18044e88885db4ff2c7ebbca4376b6e4c1b7b88b66385a33c7775b5b"} [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    Complete structured claim and evidence

  2. SSC receptor activation caused neuronal calcium influx.

    S-Sulfocysteine → Neuronal calcium influx source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"}
    experimental_model
    Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice
    exposure
    SSC/sulfite exposure; receptor/calcium/calpain inhibition
    limitations
    Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Mus musculus neurons and mice; chemical reaction assays
    plain_language
    Receptor activation opens the way for calcium to enter.
    primary_references
    [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    tissue_or_cell_type
    Neuronal receptors, intracellular calcium and inhibitory synapses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1275–1286

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice · source_derived_draft · unverified_draft

    ### mo-ssc-calcium SSC receptor activation caused neuronal calcium influx. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: Receptor activation opens the way for calcium to enter. organism: Mus musculus neurons and mice; chemical reaction assays tissue_or_cell_type: Neuronal receptors, intracellular calcium and inhibitory synapses experimental_model: Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice limitations: Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity. exposure: SSC/sulfite exposure; receptor/calcium/calpain inhibition evidence_span: {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"} [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    Complete structured claim and evidence

  3. SSC exposure activated calpain; blockade of calcium entry or calpain prevented the measured excitotoxicity.

    S-Sulfocysteine → Calcium-dependent calpain proteases source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"}
    experimental_model
    Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice
    exposure
    SSC/sulfite exposure; receptor/calcium/calpain inhibition
    limitations
    Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Mus musculus neurons and mice; chemical reaction assays
    plain_language
    Calcium-dependent proteases connect the signal to cellular damage.
    primary_references
    [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    tissue_or_cell_type
    Neuronal receptors, intracellular calcium and inhibitory synapses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1288–1299

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice · source_derived_draft · unverified_draft

    ### mo-ssc-calpain SSC exposure activated calpain; blockade of calcium entry or calpain prevented the measured excitotoxicity. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium-dependent proteases connect the signal to cellular damage. organism: Mus musculus neurons and mice; chemical reaction assays tissue_or_cell_type: Neuronal receptors, intracellular calcium and inhibitory synapses experimental_model: Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice limitations: Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity. exposure: SSC/sulfite exposure; receptor/calcium/calpain inhibition evidence_span: {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"} [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    Complete structured claim and evidence

  4. SSC acted as an NMDA-receptor agonist in primary murine neurons.

    S-Sulfocysteine → NMDA-type glutamate receptors source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"}
    experimental_model
    Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice
    exposure
    SSC/sulfite exposure; receptor/calcium/calpain inhibition
    limitations
    Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Mus musculus neurons and mice; chemical reaction assays
    plain_language
    A sulfur metabolite can imitate an excitatory neurotransmitter.
    primary_references
    [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    tissue_or_cell_type
    Neuronal receptors, intracellular calcium and inhibitory synapses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1249–1260

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice · source_derived_draft · unverified_draft

    ### mo-ssc-nmda SSC acted as an NMDA-receptor agonist in primary murine neurons. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: A sulfur metabolite can imitate an excitatory neurotransmitter. organism: Mus musculus neurons and mice; chemical reaction assays tissue_or_cell_type: Neuronal receptors, intracellular calcium and inhibitory synapses experimental_model: Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice limitations: Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity. exposure: SSC/sulfite exposure; receptor/calcium/calpain inhibition evidence_span: {"source_cache": "artifacts/molybdenum-research/29106383.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c", "start_char": 0, "end_char": 1472, "text_sha256": "34a677525363617e386b99e8ada3d049bc6147617c92764ca09caf1cae8efa1c"} [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    Complete structured claim and evidence

What acts on it

  1. Sulfite reacted stoichiometrically with cystine to form SSC; reduced cysteine did not form SSC in the same assay.

    Sulfite / SO3(2-) → S-Sulfocysteine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/29106383.fulltext.txt", "locator": "Exact primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d7cfb311498ba2a88e3fc04be988dcffda740bbd1d93ada686cabf801861cf2a", "start_char": 14310, "end_char": 15490, "text_sha256": "9a181fcee8488d6f7513a0fa1759320721a8663e58658ef9344c1354716e3284"}
    experimental_model
    Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice
    exposure
    SSC/sulfite exposure; receptor/calcium/calpain inhibition
    limitations
    Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Mus musculus neurons and mice; chemical reaction assays
    plain_language
    The oxidized and reduced forms of cysteine behave differently.
    primary_references
    [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    tissue_or_cell_type
    Neuronal receptors, intracellular calcium and inhibitory synapses
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1236–1247

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice · source_derived_draft · unverified_draft

    ### mo-ssc-formation Sulfite reacted stoichiometrically with cystine to form SSC; reduced cysteine did not form SSC in the same assay. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: The oxidized and reduced forms of cysteine behave differently. organism: Mus musculus neurons and mice; chemical reaction assays tissue_or_cell_type: Neuronal receptors, intracellular calcium and inhibitory synapses experimental_model: Primary murine neurons, chemical reaction assays and tungstate-induced MoCD mice limitations: Mechanistic model evidence. Mouse drug rescue does not establish human treatment efficacy; sulfite also has SSC-independent toxicity. exposure: SSC/sulfite exposure; receptor/calcium/calpain inhibition evidence_span: {"source_cache": "artifacts/molybdenum-research/29106383.fulltext.txt", "locator": "Exact primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d7cfb311498ba2a88e3fc04be988dcffda740bbd1d93ada686cabf801861cf2a", "start_char": 14310, "end_char": 15490, "text_sha256": "9a181fcee8488d6f7513a0fa1759320721a8663e58658ef9344c1354716e3284"} [mo-p29106383] S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. (2017). https://pubmed.ncbi.nlm.nih.gov/29106383/ DOI: 10.1172/jci89885
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. MoCD-A and MoCD-B patients had elevated plasma/urinary S-sulfocysteine and xanthine, while urate stayed below reference ranges.

    Molybdenum cofactor / Moco → Combined sulfur and purine biomarker pattern in Moco deficiency source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/molybdenum-research/35192225.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab9083746ef775c196770d3f4d0208378f1796abf1d7056fe5b23f60421032d4", "start_char": 0, "end_char": 1812, "text_sha256": "ab9083746ef775c196770d3f4d0208378f1796abf1d7056fe5b23f60421032d4"}
    experimental_model
    Retrospective natural history in 58 patients; prospective biomarkers in 21 survivors
    exposure
    MoCD A:41; MoCD B:17
    limitations
    Severe inherited cofactor defects; not a prevalence study of ordinary nutritional deficiency or a validated population screening threshold.
    nutrient_topic
    Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
    organism
    Homo sapiens
    plain_language
    The combined pattern reflects failures in two cofactor-dependent pathways.
    primary_references
    [mo-p35192225] Molybdenum cofactor deficiency: A natural history. (2022). https://pubmed.ncbi.nlm.nih.gov/35192225/ DOI: 10.1002/jimd.12488
    tissue_or_cell_type
    Neurological course and plasma/urine
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1158–1169

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Retrospective natural history in 58 patients; prospective biomarkers in 21 survivors · source_derived_draft · unverified_draft

    ### mo-mocd-biomarkers MoCD-A and MoCD-B patients had elevated plasma/urinary S-sulfocysteine and xanthine, while urate stayed below reference ranges. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combined pattern reflects failures in two cofactor-dependent pathways. organism: Homo sapiens tissue_or_cell_type: Neurological course and plasma/urine experimental_model: Retrospective natural history in 58 patients; prospective biomarkers in 21 survivors limitations: Severe inherited cofactor defects; not a prevalence study of ordinary nutritional deficiency or a validated population screening threshold. exposure: MoCD A:41; MoCD B:17 evidence_span: {"source_cache": "artifacts/molybdenum-research/35192225.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab9083746ef775c196770d3f4d0208378f1796abf1d7056fe5b23f60421032d4", "start_char": 0, "end_char": 1812, "text_sha256": "ab9083746ef775c196770d3f4d0208378f1796abf1d7056fe5b23f60421032d4"} [mo-p35192225] Molybdenum cofactor deficiency: A natural history. (2022). https://pubmed.ncbi.nlm.nih.gov/35192225/ DOI: 10.1002/jimd.12488
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards