Component
Ruminococcus bromii-associated deoxycholic acid biotransformation
Ruminococcus bromii-associated deoxycholic acid biotransformation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The authors linked berberine-associated glycemic improvement to inhibited Ruminococcus bromii-associated DCA biotransformation using metagenomic, metabolomic and culture evidence.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/33024120.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5dbbfd240d55ac62d2f48263f25e5543e47aa4a91d7711637fbacc543ce54bd9", "start_char": 0, "end_char": 1283, "text_sha256": "5dbbfd240d55ac62d2f48263f25e5543e47aa4a91d7711637fbacc543ce54bd9"}
- experimental_model
- Multicenter randomized double-blind four-arm trial with metagenomics and microbial validation
- exposure
- Twelve weeks of berberine, probiotics, both or placebo after one week of gentamycin pretreatment
- limitations
- Antibiotic run-in and Chinese drug-naive population limit generalization. Microbial mediation is supported but not proof it explains every effect. Probiotic addition did not show a clear extra HbA1c reduction in the reported estimates.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- 409 newly diagnosed type 2 diabetes patients; separate bacterial experiments
- plain_language
- Gut microbes and bile-acid metabolism form another supported branch, with mediation uncertainty retained.
- primary_references
- [berberine-p33024120] Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). (2020). https://pubmed.ncbi.nlm.nih.gov/33024120/ DOI: 10.1038/s41467-020-18414-8
- tissue_or_cell_type
- Glycemia, gut microbiome and bile-acid transformation
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 1156–1167
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multicenter randomized double-blind four-arm trial with metagenomics and microbial validation · source_derived_draft · unverified_draft
### berberine-premote-dca The authors linked berberine-associated glycemic improvement to inhibited Ruminococcus bromii-associated DCA biotransformation using metagenomic, metabolomic and culture evidence. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Gut microbes and bile-acid metabolism form another supported branch, with mediation uncertainty retained. organism: 409 newly diagnosed type 2 diabetes patients; separate bacterial experiments tissue_or_cell_type: Glycemia, gut microbiome and bile-acid transformation experimental_model: Multicenter randomized double-blind four-arm trial with metagenomics and microbial validation limitations: Antibiotic run-in and Chinese drug-naive population limit generalization. Microbial mediation is supported but not proof it explains every effect. Probiotic addition did not show a clear extra HbA1c reduction in the reported estimates. exposure: Twelve weeks of berberine, probiotics, both or placebo after one week of gentamycin pretreatment evidence_span: {"source_cache": "artifacts/berberine-research/33024120.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5dbbfd240d55ac62d2f48263f25e5543e47aa4a91d7711637fbacc543ce54bd9", "start_char": 0, "end_char": 1283, "text_sha256": "5dbbfd240d55ac62d2f48263f25e5543e47aa4a91d7711637fbacc543ce54bd9"} [berberine-p33024120] Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). (2020). https://pubmed.ncbi.nlm.nih.gov/33024120/ DOI: 10.1038/s41467-020-18414-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.