Component
Human ribonucleotide reductase small subunit RRM2
Human ribonucleotide reductase small subunit RRM2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human RRM2 radical-center tyrosine mutations abolished the detectable stable radical and ribonucleotide-reductase activity in the tested assays.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/16373698.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d3e9b3d6c8961f94af38195eab5b0b3180c321da1c7ca75ae956036a60b16cc", "start_char": 0, "end_char": 1165, "text_sha256": "0d3e9b3d6c8961f94af38195eab5b0b3180c321da1c7ca75ae956036a60b16cc"}
- experimental_model
- Mutagenesis, EPR and catalytic assays
- exposure
- Conserved tyrosine mutations around the diiron center
- limitations
- Purified enzyme mechanisms; no recommendation to increase dietary iron for DNA synthesis.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Human RRM2 and RRM2B proteins
- plain_language
- DNA building-block synthesis needs a functioning iron/radical enzyme system.
- primary_references
- [iron-p16373698] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases. (2005). https://pubmed.ncbi.nlm.nih.gov/16373698/ DOI: 10.1158/1535-7163.mct-05-0273
- tissue_or_cell_type
- Ribonucleotide reductase small subunits
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1174–1185
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mutagenesis, EPR and catalytic assays · source_derived_draft · unverified_draft
### iron-rrm2-iron-radical Human RRM2 radical-center tyrosine mutations abolished the detectable stable radical and ribonucleotide-reductase activity in the tested assays. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: DNA building-block synthesis needs a functioning iron/radical enzyme system. organism: Human RRM2 and RRM2B proteins tissue_or_cell_type: Ribonucleotide reductase small subunits experimental_model: Mutagenesis, EPR and catalytic assays limitations: Purified enzyme mechanisms; no recommendation to increase dietary iron for DNA synthesis. exposure: Conserved tyrosine mutations around the diiron center evidence_span: {"source_cache": "artifacts/iron-research/16373698.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d3e9b3d6c8961f94af38195eab5b0b3180c321da1c7ca75ae956036a60b16cc", "start_char": 0, "end_char": 1165, "text_sha256": "0d3e9b3d6c8961f94af38195eab5b0b3180c321da1c7ca75ae956036a60b16cc"} [iron-p16373698] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases. (2005). https://pubmed.ncbi.nlm.nih.gov/16373698/ DOI: 10.1158/1535-7163.mct-05-0273
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.