Component
Rodent food intake
Rodent food intake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Reactivating hypothalamic AMPK reversed lipoic-acid effects on food intake and energy expenditure.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/15195087.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6fcce42055285979267d9a0f58b3c7e9fb221b549db47d2f508b3fb2112ad493", "start_char": 0, "end_char": 1001, "text_sha256": "6fcce42055285979267d9a0f58b3c7e9fb221b549db47d2f508b3fb2112ad493"}
- experimental_model
- Rodent feeding, energy expenditure and hypothalamic AMPK manipulation
- exposure
- Alpha-lipoic acid with central AMPK manipulation
- limitations
- Central effects must not be generalized to AMPK in all tissues or to human weight-loss outcomes.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Rodents
- plain_language
- Manipulating the brain pathway changed the feeding response.
- primary_references
- [ala-p15195087] Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. (2004). https://pubmed.ncbi.nlm.nih.gov/15195087/ DOI: 10.1038/nm1061
- tissue_or_cell_type
- Hypothalamus and whole-animal energy balance
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 988–999
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent feeding, energy expenditure and hypothalamic AMPK manipulation · source_derived_draft · unverified_draft
### ala-hypothalamic-feeding Reactivating hypothalamic AMPK reversed lipoic-acid effects on food intake and energy expenditure. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Manipulating the brain pathway changed the feeding response. organism: Rodents tissue_or_cell_type: Hypothalamus and whole-animal energy balance experimental_model: Rodent feeding, energy expenditure and hypothalamic AMPK manipulation limitations: Central effects must not be generalized to AMPK in all tissues or to human weight-loss outcomes. exposure: Alpha-lipoic acid with central AMPK manipulation evidence_span: {"source_cache": "artifacts/ala-research/15195087.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6fcce42055285979267d9a0f58b3c7e9fb221b549db47d2f508b3fb2112ad493", "start_char": 0, "end_char": 1001, "text_sha256": "6fcce42055285979267d9a0f58b3c7e9fb221b549db47d2f508b3fb2112ad493"} [ala-p15195087] Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. (2004). https://pubmed.ncbi.nlm.nih.gov/15195087/ DOI: 10.1038/nm1061
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.