Component
The 60S ribosomal subunit
The 60S ribosomal subunit. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Cells overexpressing Rbm3 showed a three-fold increase in protein synthesis at both 37 and 32 degrees C, a fraction of Rbm3 associated with 60S ribosomal subunits in an RNA-independent manner, and a microRNA-containing complex was less abundant in those cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/15684048.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "662a7c449d01ae63eabee803791ad8154faa37eb62f60ccf58aabc3bd355d7e5", "start_char": 0, "end_char": 1694, "text_sha256": "662a7c449d01ae63eabee803791ad8154faa37eb62f60ccf58aabc3bd355d7e5"}
- experimental_model
- Mouse neuroblastoma cells overexpressing Rbm3 as a c-Myc fusion protein at 37 and 32 degrees C
- exposure
- Mild hypothermia at 32 degrees C with Rbm3 overexpression
- limitations
- A cell-culture overexpression study. The microRNA explanation is offered as a possibility by the authors rather than demonstrated.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Mouse cells
- plain_language
- The cold-induced protein makes cells build more protein, and it sits on the ribosome to do it.
- primary_references
- [cold-p15684048] Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. (2005). https://pubmed.ncbi.nlm.nih.gov/15684048/ DOI: 10.1073/pnas.0409764102
- tissue_or_cell_type
- Neuroblastoma cells
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 897–908
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse neuroblastoma cells overexpressing Rbm3 as a c-Myc fusion protein at 37 and 32 degrees C · source_derived_draft · unverified_draft
### cold-rbm3-protein-synthesis Cells overexpressing Rbm3 showed a three-fold increase in protein synthesis at both 37 and 32 degrees C, a fraction of Rbm3 associated with 60S ribosomal subunits in an RNA-independent manner, and a microRNA-containing complex was less abundant in those cells. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The cold-induced protein makes cells build more protein, and it sits on the ribosome to do it. organism: Mouse cells tissue_or_cell_type: Neuroblastoma cells experimental_model: Mouse neuroblastoma cells overexpressing Rbm3 as a c-Myc fusion protein at 37 and 32 degrees C limitations: A cell-culture overexpression study. The microRNA explanation is offered as a possibility by the authors rather than demonstrated. exposure: Mild hypothermia at 32 degrees C with Rbm3 overexpression evidence_span: {"source_cache": "artifacts/cold-research/15684048.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "662a7c449d01ae63eabee803791ad8154faa37eb62f60ccf58aabc3bd355d7e5", "start_char": 0, "end_char": 1694, "text_sha256": "662a7c449d01ae63eabee803791ad8154faa37eb62f60ccf58aabc3bd355d7e5"} [cold-p15684048] Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. (2005). https://pubmed.ncbi.nlm.nih.gov/15684048/ DOI: 10.1073/pnas.0409764102
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.