Component
All-trans-retinyl linoleate
Linoleate ester of all-trans-retinol.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Figure 3
- experimental_model
- Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.
- exposure
- 6 micrograms retinol in peanut oil; P-407 clearance blockade; sampling at three hours.
- limitations
- Clearance was pharmacologically blocked; remaining enzyme identity was not established here.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- outcome
- Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil.
- plain_language
- Alternative esterification partly handles absorbed retinol when LRAT is missing.
- primary_references
- [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
- tissue_or_cell_type
- Intestine and isolated chylomicrons
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 346–358
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. · source_derived_draft · unverified_draft
### va-lrat-chylomicron-retinoids Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Alternative esterification partly handles absorbed retinol when LRAT is missing. organism: Mus musculus tissue_or_cell_type: Intestine and isolated chylomicrons experimental_model: Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. limitations: Clearance was pharmacologically blocked; remaining enzyme identity was not established here. exposure: 6 micrograms retinol in peanut oil; P-407 clearance blockade; sampling at three hours. outcome: Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil. evidence_location: Figure 3 [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.