Component
Retinal taurine concentration
Retinal taurine concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
A close relationship between vigabatrin-induced retinal toxicity and light exposure was observed, vigabatrin-treated mice reared in darkness preserved better visual function and retinal architectures as verified by optokinetic tests, optical coherence tomography and electroretinography, the retinal taurine level of vigabatrin-treated mice exposed to light was significantly lower than that of vigabatrin mice reared in darkness, and the vigabatrin-induced morphological and functional impairments could be partially alleviated by taurine treatment.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/27941319.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "92835398ef34fe87d3c084d1933722427a474b40c88c30ada21a6ede8f4d875a", "start_char": 0, "end_char": 1596, "text_sha256": "92835398ef34fe87d3c084d1933722427a474b40c88c30ada21a6ede8f4d875a"}
- experimental_model
- Electroretinography, optical coherence tomography and optokinetic testing in mice reared in light or darkness
- exposure
- Vigabatrin with and without light exposure, and with taurine supplementation
- limitations
- A mouse study. It identifies two contributing factors and shows partial rescue, not that taurine prevents the human visual field defect.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Mouse
- plain_language
- The retinal damage needed light to happen, went with a fall in retinal taurine, and was partly undone by giving taurine back.
- primary_references
- [gb-p27941319] The Vigabatrin Induced Retinal Toxicity is Associated with Photopic Exposure and Taurine Deficiency: An In Vivo Study. (2016). https://pubmed.ncbi.nlm.nih.gov/27941319/ DOI: 10.1159/000453143
- tissue_or_cell_type
- Retina
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Electroretinography, optical coherence tomography and optokinetic testing in mice reared in light or darkness · source_derived_draft · unverified_draft
### gb-light-and-taurine-both-matter A close relationship between vigabatrin-induced retinal toxicity and light exposure was observed, vigabatrin-treated mice reared in darkness preserved better visual function and retinal architectures as verified by optokinetic tests, optical coherence tomography and electroretinography, the retinal taurine level of vigabatrin-treated mice exposed to light was significantly lower than that of vigabatrin mice reared in darkness, and the vigabatrin-induced morphological and functional impairments could be partially alleviated by taurine treatment. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: The retinal damage needed light to happen, went with a fall in retinal taurine, and was partly undone by giving taurine back. organism: Mouse tissue_or_cell_type: Retina experimental_model: Electroretinography, optical coherence tomography and optokinetic testing in mice reared in light or darkness limitations: A mouse study. It identifies two contributing factors and shows partial rescue, not that taurine prevents the human visual field defect. exposure: Vigabatrin with and without light exposure, and with taurine supplementation evidence_span: {"source_cache": "artifacts/gaba-research/27941319.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "92835398ef34fe87d3c084d1933722427a474b40c88c30ada21a6ede8f4d875a", "start_char": 0, "end_char": 1596, "text_sha256": "92835398ef34fe87d3c084d1933722427a474b40c88c30ada21a6ede8f4d875a"} [gb-p27941319] The Vigabatrin Induced Retinal Toxicity is Associated with Photopic Exposure and Taurine Deficiency: An In Vivo Study. (2016). https://pubmed.ncbi.nlm.nih.gov/27941319/ DOI: 10.1159/000453143
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.