Component
Respiratory quotient
Respiratory quotient. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In the 1977 case, intravenous chromium was followed by normalization of the measured glucose-tolerance rate and respiratory quotient after two weeks, with insulin subsequently no longer required.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chromium-research/192066.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "77f1130259582a7565cecbf7bf6d04dd0f54fb6c54ebf8d4498341c48ec3cd8c", "start_char": 0, "end_char": 1943, "text_sha256": "77f1130259582a7565cecbf7bf6d04dd0f54fb6c54ebf8d4498341c48ec3cd8c"}
- experimental_model
- Historical long-term parenteral-nutrition case report
- exposure
- More than five years of parenteral nutrition; 250 µg chromium/day added for two weeks after impaired glucose tolerance and neuropathy
- limitations
- Single uncontrolled case with complex nutrition and treatment changes. Historical blood/hair reference ranges are not validated current diagnostic thresholds; response to pharmacological chromium does not by itself prove an essential dietary requirement.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Human adult patient
- plain_language
- The patient improved after chromium was added to intravenous nutrition, but a single case cannot establish the general mechanism.
- primary_references
- [chromium-p192066] Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. (1977). https://pubmed.ncbi.nlm.nih.gov/192066/ DOI: 10.1093/ajcn/30.4.531
- tissue_or_cell_type
- Systemic glucose utilization and peripheral nerves
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 887–898
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical long-term parenteral-nutrition case report · source_derived_draft · unverified_draft
### chromium-parenteral-glucose-1977 In the 1977 case, intravenous chromium was followed by normalization of the measured glucose-tolerance rate and respiratory quotient after two weeks, with insulin subsequently no longer required. Condition category: nutrient_deficiency nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The patient improved after chromium was added to intravenous nutrition, but a single case cannot establish the general mechanism. organism: Human adult patient tissue_or_cell_type: Systemic glucose utilization and peripheral nerves experimental_model: Historical long-term parenteral-nutrition case report limitations: Single uncontrolled case with complex nutrition and treatment changes. Historical blood/hair reference ranges are not validated current diagnostic thresholds; response to pharmacological chromium does not by itself prove an essential dietary requirement. exposure: More than five years of parenteral nutrition; 250 µg chromium/day added for two weeks after impaired glucose tolerance and neuropathy evidence_span: {"source_cache": "artifacts/chromium-research/192066.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "77f1130259582a7565cecbf7bf6d04dd0f54fb6c54ebf8d4498341c48ec3cd8c", "start_char": 0, "end_char": 1943, "text_sha256": "77f1130259582a7565cecbf7bf6d04dd0f54fb6c54ebf8d4498341c48ec3cd8c"} [chromium-p192066] Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. (1977). https://pubmed.ncbi.nlm.nih.gov/192066/ DOI: 10.1093/ajcn/30.4.531
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.