Component
Respiratory frequency and tidal volume
Respiratory frequency and tidal volume. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Repeated immersions of one body side reduced heart rate and respiratory frequency and volume responses, and reduced the responses evoked on the opposite, previously unhabituated side, despite identical skin temperature profiles, placing the habituation mechanism more centrally than the peripheral receptors.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/9763650.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47", "start_char": 0, "end_char": 1204, "text_sha256": "0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47"}
- experimental_model
- Two groups immersing contralateral body sides in stirred water at 10 degrees C
- exposure
- Two 3-minute head-out immersions at 10 degrees C, with six further immersions of the opposite side between them
- limitations
- A crossed-side design that separates central from peripheral habituation. Skin temperature profiles were identical between groups, which is what makes the conclusion interpretable.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Human
- plain_language
- Practising on one side of the body calms the response on the other, so the adaptation is in the brain, not the skin.
- primary_references
- [cold-p9763650] Habituation of the initial responses to cold water immersion in humans: a central or peripheral mechanism? (1998). https://pubmed.ncbi.nlm.nih.gov/9763650/ DOI: 10.1111/j.1469-7793.1998.621be.x
- tissue_or_cell_type
- Whole body
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 156–167
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two groups immersing contralateral body sides in stirred water at 10 degrees C · source_derived_draft · unverified_draft
### cold-habituation-central Repeated immersions of one body side reduced heart rate and respiratory frequency and volume responses, and reduced the responses evoked on the opposite, previously unhabituated side, despite identical skin temperature profiles, placing the habituation mechanism more centrally than the peripheral receptors. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Practising on one side of the body calms the response on the other, so the adaptation is in the brain, not the skin. organism: Human tissue_or_cell_type: Whole body experimental_model: Two groups immersing contralateral body sides in stirred water at 10 degrees C limitations: A crossed-side design that separates central from peripheral habituation. Skin temperature profiles were identical between groups, which is what makes the conclusion interpretable. exposure: Two 3-minute head-out immersions at 10 degrees C, with six further immersions of the opposite side between them evidence_span: {"source_cache": "artifacts/cold-research/9763650.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47", "start_char": 0, "end_char": 1204, "text_sha256": "0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47"} [cold-p9763650] Habituation of the initial responses to cold water immersion in humans: a central or peripheral mechanism? (1998). https://pubmed.ncbi.nlm.nih.gov/9763650/ DOI: 10.1111/j.1469-7793.1998.621be.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.