{"id":"a1c5f71f-74ca-5c98-8eb3-974f57a7064a","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-habituation-central","predicate":"reduces","statement":"Repeated immersions of one body side reduced heart rate and respiratory frequency and volume responses, and reduced the responses evoked on the opposite, previously unhabituated side, despite identical skin temperature profiles, placing the habituation mechanism more centrally than the peripheral receptors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6ebc9971-eec6-537c-9e67-6c7a3d8e561a","mechanism_event_label":"Practising on one side of the body calms the response on the other, so the adaptation is in the brain, not the skin.","subject":{"id":"8bbc0852-77a3-5fb2-8946-430ccdec6bbd","slug":"habituation-of-cold-shock","display_name":"Habituation of the initial responses to cold water immersion","entity_type_key":"cellular_process"},"object":{"id":"ea1dc1ba-02ea-5dce-8c62-bd8b9437c38e","slug":"cold-shock-response","display_name":"The cold shock response: inspiratory gasp, hyperventilation and tachycardia on immersion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6ebc9971-eec6-537c-9e67-6c7a3d8e561a","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-habituation-central-event","event_type":"biochemical_relationship","label":"Practising on one side of the body calms the response on the other, so the adaptation is in the brain, not the skin.","description":"Repeated immersions of one body side reduced heart rate and respiratory frequency and volume responses, and reduced the responses evoked on the opposite, previously unhabituated side, despite identical skin temperature profiles, placing the habituation mechanism more centrally than the peripheral receptors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"625cf272-9f5a-51af-a725-6b4b8d8dbbad","slug":"respiratory-frequency","display_name":"Respiratory frequency and tidal volume","entity_type_key":"cellular_process"},"role":"measured_response","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5c2ca60f-0af2-5b25-b2ea-f75beda1f335","slug":"heart-rate","display_name":"Heart rate","entity_type_key":"cellular_process"},"role":"measured_response","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8bbc0852-77a3-5fb2-8946-430ccdec6bbd","slug":"habituation-of-cold-shock","display_name":"Habituation of the initial responses to cold water immersion","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ea1dc1ba-02ea-5dce-8c62-bd8b9437c38e","slug":"cold-shock-response","display_name":"The cold shock response: inspiratory gasp, hyperventilation and tachycardia on immersion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/9763650.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47\", \"start_char\": 0, \"end_char\": 1204, \"text_sha256\": \"0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two groups immersing contralateral body sides in stirred water at 10 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Two 3-minute head-out immersions at 10 degrees C, with six further immersions of the opposite side between them","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A crossed-side design that separates central from peripheral habituation. Skin temperature profiles were identical between groups, which is what makes the conclusion interpretable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Practising on one side of the body calms the response on the other, so the adaptation is in the brain, not the skin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p9763650] Habituation of the initial responses to cold water immersion in humans: a central or peripheral mechanism? 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Skin temperature profiles were identical between groups, which is what makes the conclusion interpretable.\nexposure: Two 3-minute head-out immersions at 10 degrees C, with six further immersions of the opposite side between them\nevidence_span: {\"source_cache\": \"artifacts/cold-research/9763650.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47\", \"start_char\": 0, \"end_char\": 1204, \"text_sha256\": \"0f007b123776a775f6672afa5075a3085c9ddb82578ad6b8984d3da95efbfd47\"}\n[cold-p9763650] Habituation of the initial responses to cold water immersion in humans: a central or peripheral mechanism? 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