Component
Renal folate uptake
Renal folate uptake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Ethanol reduces intestinal and renal uptake of folate by altering the binding and transport kinetics of folate transport systems and by reducing the expression of folate transporters, with ethanol ingestion described as the major contributor to folate deficiency.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/19292860.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30", "start_char": 0, "end_char": 2909, "text_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30"}
- experimental_model
- Review of folate transport systems in relation to alcoholism-induced malabsorption
- exposure
- Chronic ethanol ingestion against folate transport
- limitations
- A review, labelled as such, used for the enumeration of routes. The individual transport measurements are recorded from their own primary papers where available.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human and animal
- plain_language
- Alcohol attacks the vitamin at the doorway, in both gut and kidney.
- primary_references
- [alcohol-p19292860] New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. (2009). https://pubmed.ncbi.nlm.nih.gov/19292860/ DOI: 10.1111/j.1742-4658.2009.06959.x
- tissue_or_cell_type
- Intestine, liver and kidney
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 683–694
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Review of folate transport systems in relation to alcoholism-induced malabsorption · source_derived_draft · unverified_draft
### alcohol-ethanol-folate-transport Ethanol reduces intestinal and renal uptake of folate by altering the binding and transport kinetics of folate transport systems and by reducing the expression of folate transporters, with ethanol ingestion described as the major contributor to folate deficiency. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Alcohol attacks the vitamin at the doorway, in both gut and kidney. organism: Human and animal tissue_or_cell_type: Intestine, liver and kidney experimental_model: Review of folate transport systems in relation to alcoholism-induced malabsorption limitations: A review, labelled as such, used for the enumeration of routes. The individual transport measurements are recorded from their own primary papers where available. exposure: Chronic ethanol ingestion against folate transport evidence_span: {"source_cache": "artifacts/alcohol-research/19292860.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30", "start_char": 0, "end_char": 2909, "text_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30"} [alcohol-p19292860] New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. (2009). https://pubmed.ncbi.nlm.nih.gov/19292860/ DOI: 10.1111/j.1742-4658.2009.06959.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.