Component

Human erythrocyte glutathione concentration, study-defined assay pool

Human erythrocyte glutathione concentration, study-defined assay pool. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. At six months, high-dose erythrocyte GSH increased within the reported 30–35% range versus baseline.

    Oral reduced glutathione regimens in the 2015 trial → Human erythrocyte glutathione concentration, study-defined assay pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/glutathione-research/24791752.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388", "start_char": 0, "end_char": 1596, "text_sha256": "b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388"}
    experimental_model
    Six-month randomized double-blind placebo-controlled trial
    exposure
    250 or 1000 mg/day oral GSH; one-month washout
    limitations
    Pool increases reported relative to baseline; NK comparison was versus placebo. Biomarkers do not prove fewer illnesses or longer life.
    nutrient_topic
    Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
    organism
    Human
    plain_language
    The measured compartment increased in the longer trial.
    primary_references
    [glutathione-p24791752] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015). https://pubmed.ncbi.nlm.nih.gov/24791752/ DOI: 10.1007/s00394-014-0706-z
    tissue_or_cell_type
    54 nonsmoking adults; immune subset

    Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1178–1189

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-month randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft

    ### glutathione-oral-2015-rbc At six months, high-dose erythrocyte GSH increased within the reported 30–35% range versus baseline. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured compartment increased in the longer trial. organism: Human tissue_or_cell_type: 54 nonsmoking adults; immune subset experimental_model: Six-month randomized double-blind placebo-controlled trial limitations: Pool increases reported relative to baseline; NK comparison was versus placebo. Biomarkers do not prove fewer illnesses or longer life. exposure: 250 or 1000 mg/day oral GSH; one-month washout evidence_span: {"source_cache": "artifacts/glutathione-research/24791752.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388", "start_char": 0, "end_char": 1596, "text_sha256": "b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388"} [glutathione-p24791752] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015). https://pubmed.ncbi.nlm.nih.gov/24791752/ DOI: 10.1007/s00394-014-0706-z
    Complete structured claim and evidence

  2. The older group’s erythrocyte GSH concentration increased 94.6% after supplementation.

    Glycine plus cysteine-precursor supplementation in the 2011 tracer study → Human erythrocyte glutathione concentration, study-defined assay pool source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/glutathione-research/21795440.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd", "start_char": 0, "end_char": 2139, "text_sha256": "97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd"}
    experimental_model
    Stable-isotope tracer study with before/after supplementation
    exposure
    Two weeks of glycine/cysteine-precursor supplementation in older participants
    limitations
    Small non-placebo-controlled intervention; age comparison and treatment response are not universal aging rules.
    nutrient_topic
    Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
    organism
    Human
    plain_language
    A low measured pool increased in this small study.
    primary_references
    [glutathione-p21795440] Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. (2011). https://pubmed.ncbi.nlm.nih.gov/21795440/ DOI: 10.3945/ajcn.110.003483
    tissue_or_cell_type
    Eight older and eight younger adults; erythrocytes
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1126–1137

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope tracer study with before/after supplementation · source_derived_draft · unverified_draft

    ### glutathione-precursor-pool The older group’s erythrocyte GSH concentration increased 94.6% after supplementation. Condition category: nutrient_deficiency nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low measured pool increased in this small study. organism: Human tissue_or_cell_type: Eight older and eight younger adults; erythrocytes experimental_model: Stable-isotope tracer study with before/after supplementation limitations: Small non-placebo-controlled intervention; age comparison and treatment response are not universal aging rules. exposure: Two weeks of glycine/cysteine-precursor supplementation in older participants evidence_span: {"source_cache": "artifacts/glutathione-research/21795440.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd", "start_char": 0, "end_char": 2139, "text_sha256": "97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd"} [glutathione-p21795440] Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. (2011). https://pubmed.ncbi.nlm.nih.gov/21795440/ DOI: 10.3945/ajcn.110.003483
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards