Component
Rat clotting-time endpoints with TSA
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
TSA showed the recorded no detected change in Rat clotting-time endpoints with TSA.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract reviewed; full results, tables and supplements not independently extracted.
- experimental_model
- Triacetylshikimic acid rat experiments; indexed abstract.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Derivative-specific result. Unextracted dose/time remain unspecified; no transfer to shikimic acid.
- plain_language
- TSA showed the recorded no detected change in Rat clotting-time endpoints with TSA.
- primary_references
- Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. | 2016 | DOI 10.3109/13880209.2016.1153663 | PMID 27609150 | https://pubmed.ncbi.nlm.nih.gov/27609150/ | https://doi.org/10.3109/13880209.2016.1153663
- primary_references
- Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats. | 2002 | DOI 10.1097/00005344-200202000-00013 | PMID 11791012 | https://pubmed.ncbi.nlm.nih.gov/11791012/ | https://doi.org/10.1097/00005344-200202000-00013
- primary_references
- Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats. | 2012 | DOI 10.1007/s10620-012-2155-y | PMID 22476587 | https://pubmed.ncbi.nlm.nih.gov/22476587/ | https://doi.org/10.1007/s10620-012-2155-y
- source_locator
- Reviewed reference lines 57-57; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 57–57
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Triacetylshikimic acid rat experiments; indexed abstract. · source_derived_draft · unverified_draft
**Derivatives keep their own outcomes.** Triacetylshikimic acid (TSA) reduced stimulated platelet aggregation and shunt thrombosis in rat experiments; reported cAMP increased, while cGMP, thromboxane/prostacyclin metabolites and clotting-time endpoints included null results. Those results are not assigned to parent shikimic acid. The separately tested 3,4-O-isopropylidene derivative (ISA) has rodent inflammatory/pain studies and cell-free radical-scavenging assays. Structural similarity does not establish interchangeable pharmacokinetics, targets or safety. [Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats.](https://pubmed.ncbi.nlm.nih.gov/11791012/) [Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats.](https://pubmed.ncbi.nlm.nih.gov/22476587/) [Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.](https://pubmed.ncbi.nlm.nih.gov/27609150/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.