Component
Rat multidrug and toxin extrusion protein 1 / Mate1
Rat multidrug and toxin extrusion protein 1 / Mate1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Berberine inhibited rat MATE1-mediated metformin transport, with IC50 10.7 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/30428337.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d35cfbe70c74323ef13e51af7affae3f13a4ff7b80a1d278620b8ced217346d8", "start_char": 0, "end_char": 1775, "text_sha256": "d35cfbe70c74323ef13e51af7affae3f13a4ff7b80a1d278620b8ced217346d8"}
- experimental_model
- Oral rat pharmacokinetics, intestinal sacs and rat-transporter-expressing cells
- exposure
- Oral metformin/berberine coadministration; concentration-dependent transport assays
- limitations
- Route differs from the intravenous rat study. Changes in plasma, kidney tissue and excretion are separate outcomes; not proof of improved human combination efficacy.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Rats and recombinant rat OCT1, OCT2 and MATE1
- plain_language
- This identifies the rat transporter independently, preserving species.
- primary_references
- [berberine-p30428337] Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine. (2019). https://pubmed.ncbi.nlm.nih.gov/30428337/ DOI: 10.1016/j.ejps.2018.11.010
- tissue_or_cell_type
- Intestinal uptake, kidney distribution and excretion
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 831–842
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral rat pharmacokinetics, intestinal sacs and rat-transporter-expressing cells · source_derived_draft · unverified_draft
### berberine-rat-metformin-rat-slc47a1 Berberine inhibited rat MATE1-mediated metformin transport, with IC50 10.7 micromolar. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This identifies the rat transporter independently, preserving species. organism: Rats and recombinant rat OCT1, OCT2 and MATE1 tissue_or_cell_type: Intestinal uptake, kidney distribution and excretion experimental_model: Oral rat pharmacokinetics, intestinal sacs and rat-transporter-expressing cells limitations: Route differs from the intravenous rat study. Changes in plasma, kidney tissue and excretion are separate outcomes; not proof of improved human combination efficacy. exposure: Oral metformin/berberine coadministration; concentration-dependent transport assays evidence_span: {"source_cache": "artifacts/berberine-research/30428337.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d35cfbe70c74323ef13e51af7affae3f13a4ff7b80a1d278620b8ced217346d8", "start_char": 0, "end_char": 1775, "text_sha256": "d35cfbe70c74323ef13e51af7affae3f13a4ff7b80a1d278620b8ced217346d8"} [berberine-p30428337] Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine. (2019). https://pubmed.ncbi.nlm.nih.gov/30428337/ DOI: 10.1016/j.ejps.2018.11.010
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.