Component
Rat glucose transporter 3 / Slc2a3
Rat glucose transporter 3 / Slc2a3. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The chromium-histidinate-plus-biotin condition gave the highest reported GLUT3 protein levels among the compared high-fat-diet interventions in brain and liver.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/30680172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e98d2ad542eca99d6726b7fb592f311b609e32c0b071375979fb1b79b632c2", "start_char": 0, "end_char": 1282, "text_sha256": "71e98d2ad542eca99d6726b7fb592f311b609e32c0b071375979fb1b79b632c2"}
- experimental_model
- Six-group high-fat-diet supplementation experiment
- exposure
- 42 rats; biotin alone or with chromium histidinate, picolinate or both; 12-week exposure
- limitations
- No chromium-only group in this design. Protein abundance is not proof of a direct target or human cognitive benefit. Product supplied by Nutrition 21; compound-specific comparisons remain scoped.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Male Sprague-Dawley rats
- plain_language
- This combination changed GLUT3 abundance in the rat experiment; the independent contribution of chromium was not isolated.
- primary_references
- [chromium-p30680172] Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high-fat diet. (2019). https://pubmed.ncbi.nlm.nih.gov/30680172/ DOI: 10.1002/fsn3.851
- tissue_or_cell_type
- Brain, liver and systemic metabolism
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 731–742
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-group high-fat-diet supplementation experiment · source_derived_draft · unverified_draft
### chromium-biotin-rat-glut3 The chromium-histidinate-plus-biotin condition gave the highest reported GLUT3 protein levels among the compared high-fat-diet interventions in brain and liver. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: This combination changed GLUT3 abundance in the rat experiment; the independent contribution of chromium was not isolated. organism: Male Sprague-Dawley rats tissue_or_cell_type: Brain, liver and systemic metabolism experimental_model: Six-group high-fat-diet supplementation experiment limitations: No chromium-only group in this design. Protein abundance is not proof of a direct target or human cognitive benefit. Product supplied by Nutrition 21; compound-specific comparisons remain scoped. exposure: 42 rats; biotin alone or with chromium histidinate, picolinate or both; 12-week exposure evidence_span: {"source_cache": "artifacts/chromium-research/30680172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71e98d2ad542eca99d6726b7fb592f311b609e32c0b071375979fb1b79b632c2", "start_char": 0, "end_char": 1282, "text_sha256": "71e98d2ad542eca99d6726b7fb592f311b609e32c0b071375979fb1b79b632c2"} [chromium-p30680172] Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high-fat diet. (2019). https://pubmed.ncbi.nlm.nih.gov/30680172/ DOI: 10.1002/fsn3.851
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.