Component
Rat vesicular glutamate transporter 2 / Slc17a6
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Acetoacetate reversibly inhibited reconstituted rat VGLUT2 uptake with a chloride-dependent shift consistent with competition at allosteric regulation.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Purified rat transporter; controlled chloride/acetoacetate concentrations and washout.
- limitations
- This mechanism alone does not establish the effects of fasting or a ketogenic diet in humans.
- nutrient_topic
- L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
- plain_language
- A metabolic fuel-related molecule altered transmitter packaging in a biochemical system.
- primary_references
- Metabolic control of vesicular glutamate transport and release. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20920794/ · DOI 10.1016/j.neuron.2010.09.002
L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 282–288
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified rat transporter; controlled chloride/acetoacetate concentrations and washout. · source_derived_draft · unverified_draft
## glutamate-vglut2-acetoacetate A metabolic fuel-related molecule altered transmitter packaging in a biochemical system. Acetoacetate reversibly inhibited reconstituted rat VGLUT2 uptake with a chloride-dependent shift consistent with competition at allosteric regulation. Model: Purified rat transporter; controlled chloride/acetoacetate concentrations and washout. Limitations: This mechanism alone does not establish the effects of fasting or a ketogenic diet in humans. Evidence access: Primary full text Metabolic control of vesicular glutamate transport and release. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20920794/ · DOI 10.1016/j.neuron.2010.09.002
Complete structured claim and evidenceChloride activated glutamate uptake by purified rat VGLUT2 in reconstituted proteoliposomes.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Rat VGLUT2 expressed in insect cells, purified and reconstituted; membrane-potential-driven uptake.
- limitations
- Chloride regulation in vesicles is not equivalent to an effect of dietary salt.
- nutrient_topic
- L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
- plain_language
- An ion regulates whether the vesicle-loading transporter works.
- primary_references
- Metabolic control of vesicular glutamate transport and release. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20920794/ · DOI 10.1016/j.neuron.2010.09.002
L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 274–280
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat VGLUT2 expressed in insect cells, purified and reconstituted; membrane-potential-driven uptake. · source_derived_draft · unverified_draft
## glutamate-vglut2-chloride An ion regulates whether the vesicle-loading transporter works. Chloride activated glutamate uptake by purified rat VGLUT2 in reconstituted proteoliposomes. Model: Rat VGLUT2 expressed in insect cells, purified and reconstituted; membrane-potential-driven uptake. Limitations: Chloride regulation in vesicles is not equivalent to an effect of dietary salt. Evidence access: Primary full text Metabolic control of vesicular glutamate transport and release. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20920794/ · DOI 10.1016/j.neuron.2010.09.002
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.