Rat MCT8 / Slc16a2: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Rat MCT8 expression increased uptake of 10 nM radiolabeled T3 approximately tenfold in Xenopus oocytes.
Rat MCT8 / Slc16a2 → Cellular triiodothyronine uptake source_derived_draftungraded
Experimental context and source evidence
evidence_locator
Primary abstract
evidence_spans
[{"source_document": "artifacts/iodine-metabolism-sources/12871948.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1490}]
experimental_model
Rat MCT8 cRNA expressed in Xenopus laevis oocytes
exposure
MCT8 cRNA; assay three days later with 10 nM 125I-labeled hormone; uptake linear for less than four minutes.
limitations
Rat transporter in an expression host; this is hormone transport, not intestinal iodide uptake.
nutrient_topic
Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
organism
Rat protein in Xenopus laevis
plain_language
MCT8 carries T3 across the cell membrane.
primary_references
[i-met-12871948] Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. (2003). https://pubmed.ncbi.nlm.nih.gov/12871948/ DOI: 10.1074/jbc.m300909200
tissue_or_cell_type
Oocyte plasma membrane
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 898–910
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat MCT8 cRNA expressed in Xenopus laevis oocytes · source_derived_draft · unverified_draft
### i-met-rat-t3 Rat MCT8 expression increased uptake of 10 nM radiolabeled T3 approximately tenfold in Xenopus oocytes. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: MCT8 carries T3 across the cell membrane. organism: Rat protein in Xenopus laevis tissue_or_cell_type: Oocyte plasma membrane experimental_model: Rat MCT8 cRNA expressed in Xenopus laevis oocytes limitations: Rat transporter in an expression host; this is hormone transport, not intestinal iodide uptake. exposure: MCT8 cRNA; assay three days later with 10 nM 125I-labeled hormone; uptake linear for less than four minutes. evidence_locator: Primary abstract evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/12871948.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1490}] [i-met-12871948] Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. (2003). https://pubmed.ncbi.nlm.nih.gov/12871948/ DOI: 10.1074/jbc.m300909200
Complete structured claim and evidence
Rat MCT8 expression increased uptake of 10 nM radiolabeled T4 approximately tenfold in Xenopus oocytes.
Rat MCT8 / Slc16a2 → Cellular thyroxine uptake source_derived_draftungraded
Experimental context and source evidence
evidence_locator
Primary abstract
evidence_spans
[{"source_document": "artifacts/iodine-metabolism-sources/12871948.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1490}]
experimental_model
Rat MCT8 cRNA expressed in Xenopus laevis oocytes
exposure
MCT8 cRNA; assay three days later with 10 nM 125I-labeled hormone; uptake linear for less than four minutes.
limitations
Rat transporter in an expression host; this is hormone transport, not intestinal iodide uptake.
nutrient_topic
Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
organism
Rat protein in Xenopus laevis
plain_language
MCT8 carries T4 across the cell membrane.
primary_references
[i-met-12871948] Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. (2003). https://pubmed.ncbi.nlm.nih.gov/12871948/ DOI: 10.1074/jbc.m300909200
tissue_or_cell_type
Oocyte plasma membrane
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 884–896
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat MCT8 cRNA expressed in Xenopus laevis oocytes · source_derived_draft · unverified_draft
### i-met-rat-t4 Rat MCT8 expression increased uptake of 10 nM radiolabeled T4 approximately tenfold in Xenopus oocytes. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: MCT8 carries T4 across the cell membrane. organism: Rat protein in Xenopus laevis tissue_or_cell_type: Oocyte plasma membrane experimental_model: Rat MCT8 cRNA expressed in Xenopus laevis oocytes limitations: Rat transporter in an expression host; this is hormone transport, not intestinal iodide uptake. exposure: MCT8 cRNA; assay three days later with 10 nM 125I-labeled hormone; uptake linear for less than four minutes. evidence_locator: Primary abstract evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/12871948.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1490}] [i-met-12871948] Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. (2003). https://pubmed.ncbi.nlm.nih.gov/12871948/ DOI: 10.1074/jbc.m300909200
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Rat MCT8 / Slc16a2