Component
Rat phosphoinositide 3-kinase enzymes
Rat phosphoinositide 3-kinase enzymes. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lipoic acid increased PI3K and Akt1 activities in L6 myotubes; wortmannin inhibited these responses.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/11375349.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111", "start_char": 0, "end_char": 1734, "text_sha256": "971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111"}
- experimental_model
- Signaling, transporter localization and glucose-uptake assays
- exposure
- 2.5 mmol/L lipoic acid; PI3K and p38 inhibitors
- limitations
- High cell-culture exposure; pharmacological inhibitors can have off-target effects; not a plasma target or patient dose.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Rat
- plain_language
- A high experimental exposure engaged part of the insulin-signaling pathway.
- primary_references
- [ala-p11375349] The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. (2001). https://pubmed.ncbi.nlm.nih.gov/11375349/ DOI: 10.2337/diabetes.50.6.1464
- tissue_or_cell_type
- L6 myotubes
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 897–908
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Signaling, transporter localization and glucose-uptake assays · source_derived_draft · unverified_draft
### ala-myotube-pi3k-akt Lipoic acid increased PI3K and Akt1 activities in L6 myotubes; wortmannin inhibited these responses. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A high experimental exposure engaged part of the insulin-signaling pathway. organism: Rat tissue_or_cell_type: L6 myotubes experimental_model: Signaling, transporter localization and glucose-uptake assays limitations: High cell-culture exposure; pharmacological inhibitors can have off-target effects; not a plasma target or patient dose. exposure: 2.5 mmol/L lipoic acid; PI3K and p38 inhibitors evidence_span: {"source_cache": "artifacts/ala-research/11375349.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111", "start_char": 0, "end_char": 1734, "text_sha256": "971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111"} [ala-p11375349] The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. (2001). https://pubmed.ncbi.nlm.nih.gov/11375349/ DOI: 10.2337/diabetes.50.6.1464
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.