Component
Rat Niemann-Pick C1-like 1 protein
Rattus norvegicus NPC1L1 expressed in Caco-2 cells in Narushima 2008.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Rat NPC1L1 overexpression mediated alpha-tocopherol uptake but did not mediate retinol uptake in the tested Caco-2 system.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- Rat NPC1L1-overexpressing human Caco-2 cells
- exposure
- Retinol compared with alpha-tocopherol uptake; dose/time not reported in abstract.
- limitations
- Substrate-specific negative result; does not prove vitamins A and E cannot interact through other routes.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Rattus norvegicus protein; Homo sapiens cells
- plain_language
- This vitamin E uptake route did not carry retinol in the same assay.
- primary_references
- [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
- tissue_or_cell_type
- Intestinal epithelial cell model
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 233–244
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat NPC1L1-overexpressing human Caco-2 cells · source_derived_draft · unverified_draft
### ve-transport-rat-npc1l1-retinol-negative Rat NPC1L1 overexpression mediated alpha-tocopherol uptake but did not mediate retinol uptake in the tested Caco-2 system. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: This vitamin E uptake route did not carry retinol in the same assay. organism: Rattus norvegicus protein; Homo sapiens cells tissue_or_cell_type: Intestinal epithelial cell model experimental_model: Rat NPC1L1-overexpressing human Caco-2 cells limitations: Substrate-specific negative result; does not prove vitamins A and E cannot interact through other routes. exposure: Retinol compared with alpha-tocopherol uptake; dose/time not reported in abstract. cross_nutrient: true [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.