Component
Lifespan and growth in methionine-restricted male F344 rats
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Reducing dietary methionine from 0.86% to 0.17% extended male F344 rat lifespan by about 30% while abolishing growth in the original experiment.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Lifelong controlled feeding of male Fischer 344 rats.
- limitations
- Not human lifespan evidence or a nutritionally appropriate target for children.
- nutrient_topic
- L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Methionine
- plain_language
- The longevity observation came with a substantial growth cost.
- primary_references
- Low methionine ingestion by rats extends life span. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8429371/ · DOI 10.1093/jn/123.2.269
L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19) · lines 356–362
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Lifelong controlled feeding of male Fischer 344 rats. · source_derived_draft · unverified_draft
## methionine-rat-lifespan-growth The longevity observation came with a substantial growth cost. Reducing dietary methionine from 0.86% to 0.17% extended male F344 rat lifespan by about 30% while abolishing growth in the original experiment. Model: Lifelong controlled feeding of male Fischer 344 rats. Limitations: Not human lifespan evidence or a nutritionally appropriate target for children. Evidence access: Primary abstract Low methionine ingestion by rats extends life span. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8429371/ · DOI 10.1093/jn/123.2.269
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.