Component
Allicin injury in rat precision-cut lung slices
Allicin injury in rat precision-cut lung slices. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Added extracellular glutathione reduced injury from allicin in Rat precision-cut lung slices.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_condition
- Same allicin exposure without added GSH present · Allicin Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Same allicin exposure without added GSH added extracellularly · GSH Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Allicin plus 1 mM extracellular GSH", "comparator": "Same allicin exposure without added GSH", "endpoint": "Added extracellular glutathione reduced injury from allicin in Rat precision-cut lung slices.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "glutathione", "state": "added extracellularly"}, {"entity_slug": "allicin", "state": "present"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Rat precision-cut lung slices; 1 mM extracellular GSH, direct allicin exposure; metabolic/LDH assays.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Quenching changes free exposure; it is not proof of intracellular repair or a validated physiological plasma GSH level.
- plain_language
- Added extracellular glutathione reduced injury from allicin in Rat precision-cut lung slices.
- primary_references
- Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor. | 2017 | DOI 10.3390/molecules22101711 | PMID 29023413 | https://pubmed.ncbi.nlm.nih.gov/29023413/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6151386/ | https://doi.org/10.3390/molecules22101711
- source_locator
- Reviewed reference lines 65-65; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 65–65
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat precision-cut lung slices; 1 mM extracellular GSH, direct allicin exposure; metabolic/LDH assays. · source_derived_draft · unverified_draft
**Laboratory antimicrobial activity.** Purified allicin inhibited multiple tested respiratory bacterial isolates, including some resistant to clinical antibiotics; susceptibility varied by organism and assay. The same investigation measured mammalian-cell and rat-lung-slice toxicity. Added glutathione reduced toxicity in those models. The experimental 1-mM glutathione condition must not be presented as a validated normal plasma concentration or a safe inhalation regimen. Luminal or surface accessibility is a hypothesis about delivery, not a calculation proving efficacy from nominal dose divided by fluid volume. [Reiter 2017](https://pmc.ncbi.nlm.nih.gov/articles/PMC6151386/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.