Component
Glutamate-evoked excitation of rat hippocampal neurons
Experimental species, exposure and limitations are retained on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Local indicaxanthin at 0.34 ng/neuron reduced glutamate-evoked excitation in rat hippocampal recordings.
Experimental context and source evidence
- dose
- Indicaxanthin 0.085-0.34 ng/neuron; glutamate challenge in selected recordings
- duration
- Acute firing measurements
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- In vivo rat hippocampal single-neuron recordings
- limitations
- Local application bypasses oral distribution. NMDAR binding was proposed by modeling, not established by this electrophysiological observation.
- nutrient_topic
- Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved. · Indicaxanthin
- organism
- In vivo rat hippocampal single-neuron recordings
- plain_language
- Local indicaxanthin at 0.34 ng/neuron reduced glutamate-evoked excitation in rat hippocampal recordings.
- primary_references
- Indicaxanthin from Opuntia ficus-indica Crosses the Blood-Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. (2015). https://pubmed.ncbi.nlm.nih.gov/26227670/ DOI: 10.1021/acs.jafc.5b02612
- route
- Local microiontophoresis
- tissue
- Hippocampus
Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 217–226
Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text. · supports · In vivo rat hippocampal single-neuron recordings · source_derived_draft · unverified_draft
## indicaxanthin-rat-glutamate-excitation Local indicaxanthin at 0.34 ng/neuron reduced glutamate-evoked excitation in rat hippocampal recordings. Model/species: In vivo rat hippocampal single-neuron recordings Tissue: Hippocampus Exposure: Indicaxanthin 0.085-0.34 ng/neuron; glutamate challenge in selected recordings Route: Local microiontophoresis Duration: Acute firing measurements Limits: Local application bypasses oral distribution. NMDAR binding was proposed by modeling, not established by this electrophysiological observation. Primary reference: Indicaxanthin from Opuntia ficus-indica Crosses the Blood-Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. (2015). https://pubmed.ncbi.nlm.nih.gov/26227670/ DOI: 10.1021/acs.jafc.5b02612 Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.