Component
Rat cortical glutathione S-transferase enzymes
Rat cortical glutathione S-transferase enzymes. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
GPx, GST and G6PD activities were unchanged after one hour but inhibited after three hours of sulfite exposure.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/25777939.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1768480178724867d4c7a98f723cfd1a0010f7973eae4a4baea3d1261a06fdd2", "start_char": 0, "end_char": 2017, "text_sha256": "1768480178724867d4c7a98f723cfd1a0010f7973eae4a4baea3d1261a06fdd2"}
- experimental_model
- Sulfite/thiosulfate incubation of rat cortical slices and cell-free GSSG
- exposure
- One- versus three-hour incubations; 10 micromolar sulfite redox observations
- limitations
- Concentration, duration and preparation matter; GPx activity is not evidence of selenium depletion.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Rattus norvegicus; cell-free comparison
- plain_language
- A short experiment and a longer one can show different stages of the same response.
- primary_references
- [mo-p25777939] In vitro evidence that sulfite impairs glutamatergic neurotransmission and inhibits glutathione metabolism-related enzymes in rat cerebral cortex. (2015). https://pubmed.ncbi.nlm.nih.gov/25777939/ DOI: 10.1016/j.ijdevneu.2015.03.005
- tissue_or_cell_type
- Cerebral cortex
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1418–1429
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sulfite/thiosulfate incubation of rat cortical slices and cell-free GSSG · source_derived_draft · unverified_draft
### mo-sulfite-gpx-time GPx, GST and G6PD activities were unchanged after one hour but inhibited after three hours of sulfite exposure. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: A short experiment and a longer one can show different stages of the same response. organism: Rattus norvegicus; cell-free comparison tissue_or_cell_type: Cerebral cortex experimental_model: Sulfite/thiosulfate incubation of rat cortical slices and cell-free GSSG limitations: Concentration, duration and preparation matter; GPx activity is not evidence of selenium depletion. exposure: One- versus three-hour incubations; 10 micromolar sulfite redox observations evidence_span: {"source_cache": "artifacts/molybdenum-research/25777939.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1768480178724867d4c7a98f723cfd1a0010f7973eae4a4baea3d1261a06fdd2", "start_char": 0, "end_char": 2017, "text_sha256": "1768480178724867d4c7a98f723cfd1a0010f7973eae4a4baea3d1261a06fdd2"} [mo-p25777939] In vitro evidence that sulfite impairs glutamatergic neurotransmission and inhibits glutathione metabolism-related enzymes in rat cerebral cortex. (2015). https://pubmed.ncbi.nlm.nih.gov/25777939/ DOI: 10.1016/j.ijdevneu.2015.03.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.