Component
Rat glutamate-cysteine ligase modifier subunit / Gclm
Rat glutamate-cysteine ligase modifier subunit / Gclm. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Older rat liver showed lower GCLC/GCLM expression and about 53% lower GCL activity than young liver.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"}
- experimental_model
- Aging-rat liver biochemistry and R-lipoic-acid intervention
- exposure
- R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours
- limitations
- Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Rat
- plain_language
- Aging changed the machinery that makes glutathione in this model.
- primary_references
- [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
- tissue_or_cell_type
- Liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 832–843
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Aging-rat liver biochemistry and R-lipoic-acid intervention · source_derived_draft · unverified_draft
### ala-aging-gcl-capacity Older rat liver showed lower GCLC/GCLM expression and about 53% lower GCL activity than young liver. Condition category: machinery_impairment nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Aging changed the machinery that makes glutathione in this model. organism: Rat tissue_or_cell_type: Liver experimental_model: Aging-rat liver biochemistry and R-lipoic-acid intervention limitations: Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy. exposure: R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours evidence_span: {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"} [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.