Component

Rat glycine amidinotransferase / Gatm

Rat glycine amidinotransferase / Gatm. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Renal AGAT synthesis fell to 21% of control and functional AGAT mRNA to 37% with creatine feeding.

    Creatine → AGAT expression and synthesis source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/6384218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507", "start_char": 0, "end_char": 1077, "text_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507"}
    experimental_model
    Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements
    exposure
    Diet supplemented with 0.3% creatine
    limitations
    Rat feedback regulation; percentages are relative to controls in this experiment, not human intake targets.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Rats
    plain_language
    The body adjusted production of the synthesis enzyme, not merely the amount of precursor in a test tube.
    primary_references
    [creatine-p6384218] Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level. (1984). https://pubmed.ncbi.nlm.nih.gov/6384218/ DOI: 10.1016/s0021-9258(20)71316-5
    tissue_or_cell_type
    Kidney

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 243–254

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements · source_derived_draft · unverified_draft

    ### creatine-feedback-agat-expression Renal AGAT synthesis fell to 21% of control and functional AGAT mRNA to 37% with creatine feeding. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The body adjusted production of the synthesis enzyme, not merely the amount of precursor in a test tube. organism: Rats tissue_or_cell_type: Kidney experimental_model: Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements limitations: Rat feedback regulation; percentages are relative to controls in this experiment, not human intake targets. exposure: Diet supplemented with 0.3% creatine evidence_span: {"source_cache": "artifacts/creatine-research/6384218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507", "start_char": 0, "end_char": 1077, "text_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507"} [creatine-p6384218] Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level. (1984). https://pubmed.ncbi.nlm.nih.gov/6384218/ DOI: 10.1016/s0021-9258(20)71316-5
    Complete structured claim and evidence

  2. Creatine feeding reduced renal AGAT activity to 26% of control in the studied rats.

    Creatine → Renal AGAT enzymatic activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/6384218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507", "start_char": 0, "end_char": 1077, "text_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507"}
    experimental_model
    Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements
    exposure
    Diet supplemented with 0.3% creatine
    limitations
    Rat feedback regulation; percentages are relative to controls in this experiment, not human intake targets.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Rats
    plain_language
    Providing creatine reduced the kidney enzyme activity used to make its precursor.
    primary_references
    [creatine-p6384218] Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level. (1984). https://pubmed.ncbi.nlm.nih.gov/6384218/ DOI: 10.1016/s0021-9258(20)71316-5
    tissue_or_cell_type
    Kidney

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 230–241

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements · source_derived_draft · unverified_draft

    ### creatine-feedback-renal-agat Creatine feeding reduced renal AGAT activity to 26% of control in the studied rats. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Providing creatine reduced the kidney enzyme activity used to make its precursor. organism: Rats tissue_or_cell_type: Kidney experimental_model: Controlled feeding with enzyme, protein-synthesis and functional-mRNA measurements limitations: Rat feedback regulation; percentages are relative to controls in this experiment, not human intake targets. exposure: Diet supplemented with 0.3% creatine evidence_span: {"source_cache": "artifacts/creatine-research/6384218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507", "start_char": 0, "end_char": 1077, "text_sha256": "12e742efaf02e310dd4a64db3d9336c23354b40d901631e61be2a0cbb9fee507"} [creatine-p6384218] Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level. (1984). https://pubmed.ncbi.nlm.nih.gov/6384218/ DOI: 10.1016/s0021-9258(20)71316-5
    Complete structured claim and evidence

  3. Creatine feeding reduced renal AGAT and circulating guanidinoacetate without reducing hepatic GAMT activity or capacity to synthesize creatine from guanidinoacetate.

    Creatine → Rat guanidinoacetate methyltransferase / Gamt source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/19017728.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee", "start_char": 0, "end_char": 1599, "text_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee"}
    experimental_model
    Rat feeding, isolated hepatocytes and in-vivo hepatic balance
    exposure
    Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments
    limitations
    Interorgan division of synthesis is established here in rats; this is not proof that human tissues never synthesize both steps locally.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Rats
    plain_language
    Feedback mainly limited precursor supply in this rat experiment; it did not switch off every synthesis step.
    primary_references
    [creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. (2009). https://pubmed.ncbi.nlm.nih.gov/19017728/ DOI: 10.1152/ajpendo.90547.2008
    tissue_or_cell_type
    Kidney, liver, plasma and isolated hepatocytes

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 295–306

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat feeding, isolated hepatocytes and in-vivo hepatic balance · source_derived_draft · unverified_draft

    ### creatine-feedback-spares-gamt-capacity Creatine feeding reduced renal AGAT and circulating guanidinoacetate without reducing hepatic GAMT activity or capacity to synthesize creatine from guanidinoacetate. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Feedback mainly limited precursor supply in this rat experiment; it did not switch off every synthesis step. organism: Rats tissue_or_cell_type: Kidney, liver, plasma and isolated hepatocytes experimental_model: Rat feeding, isolated hepatocytes and in-vivo hepatic balance limitations: Interorgan division of synthesis is established here in rats; this is not proof that human tissues never synthesize both steps locally. exposure: Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments evidence_span: {"source_cache": "artifacts/creatine-research/19017728.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee", "start_char": 0, "end_char": 1599, "text_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee"} [creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. (2009). https://pubmed.ncbi.nlm.nih.gov/19017728/ DOI: 10.1152/ajpendo.90547.2008
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards