Component
Rat alpha7-containing nicotinic acetylcholine receptors
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Kynurenic acid inhibited alpha7 nicotinic responses in cultured rat hippocampal neurons after at least four minutes, with an IC50 near 7 micromolar.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Rat hippocampal culture and slice electrophysiology.
- limitations
- Direct alpha7 inhibition is disputed by a later slice study; retain assay context rather than treating it as universal.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- One laboratory reported suppression of an acetylcholine receptor.
- primary_references
- The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11567036/ · DOI 10.1523/JNEUROSCI.21-19-07463.2001
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 290–296
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Rat hippocampal culture and slice electrophysiology. · source_derived_draft · unverified_draft
## tryptophan-kyna-alpha7-positive One laboratory reported suppression of an acetylcholine receptor. Kynurenic acid inhibited alpha7 nicotinic responses in cultured rat hippocampal neurons after at least four minutes, with an IC50 near 7 micromolar. Model: Rat hippocampal culture and slice electrophysiology. Limitations: Direct alpha7 inhibition is disputed by a later slice study; retain assay context rather than treating it as universal. Evidence access: Primary abstract The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11567036/ · DOI 10.1523/JNEUROSCI.21-19-07463.2001
Complete structured claim and evidenceKynurenic acid did not inhibit choline-evoked alpha7 currents in rat hippocampal slice interneurons, contrasting with earlier reports.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Adolescent rat stratum-radiatum interneurons in acute slices.
- limitations
- Slice age, temperature, agonist delivery and receptor environment are candidate explanations, not a demonstrated resolution.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- Another experiment did not reproduce the claimed receptor block.
- primary_references
- Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22848433/ · DOI 10.1371/journal.pone.0041108
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 298–304
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Adolescent rat stratum-radiatum interneurons in acute slices. · source_derived_draft · unverified_draft
## tryptophan-kyna-alpha7-rat-null Another experiment did not reproduce the claimed receptor block. Kynurenic acid did not inhibit choline-evoked alpha7 currents in rat hippocampal slice interneurons, contrasting with earlier reports. Model: Adolescent rat stratum-radiatum interneurons in acute slices. Limitations: Slice age, temperature, agonist delivery and receptor environment are candidate explanations, not a demonstrated resolution. Evidence access: Primary abstract Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22848433/ · DOI 10.1371/journal.pone.0041108
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.