Component
Rat Ano1 messenger RNA
Transcript abundance, distinct from channel protein activity.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ano1 mRNA abundance did not significantly change after 24 hours of excess iodide.
Experimental context and source evidence
- experimental_model
- Rat thyroid PCCl3 cells; 1 mM NaI unless specified.
- exposure_category
- Experimental iodide excess; normal is the schema category outside deficiency, machinery impairment and biomarker context.
- limitations
- Nonpolarized cells; concurrent changes do not establish pendrin necessity, human protection, or an intake threshold.
- measurement
- Real-time PCR; Figure 6.
- nutrient_topic
- Iodine · Iodine
- primary_references
- Calil-Silveira et al. (2016). Iodide excess regulates its own efflux: a possible involvement of pendrin. DOI: 10.1152/ajpcell.00210.2015. https://pubmed.ncbi.nlm.nih.gov/26791486/
Iodine addendum: iodide excess and cellular export (2026-09-18) · lines 25–27
Calil-Silveira et al. (2016). Iodide excess regulates its own efflux: a possible involvement of pendrin. DOI: 10.1152/ajpcell.00210.2015. https://pubmed.ncbi.nlm.nih.gov/26791486/ · supports · Rat thyroid PCCl3 cells; 1 mM NaI unless specified. · source_derived_draft · unverified_draft
## ano1-null Ano1 mRNA abundance did not significantly change after 24 hours of excess iodide. Measurement: Real-time PCR; Figure 6.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.