Component
Radiotherapy
Radiotherapy. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In meningioma cell lines the half-maximal inhibitory concentration for mebendazole was 0.26 to 0.42 micromolar, mebendazole alone induced cytotoxicity but the combination with radiation gave a greater reduction in colony formation and higher levels of cleaved caspase-3, and in mice implanted intracranially with human meningioma both mebendazole alone and the combination gave a survival benefit with increased apoptosis and decreased tumour cell and vascular proliferation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/30414098.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34445c01e56a2bfa33e4d1118f86c291fab041b15fa08da37592f4ec92d81400", "start_char": 0, "end_char": 1743, "text_sha256": "34445c01e56a2bfa33e4d1118f86c291fab041b15fa08da37592f4ec92d81400"}
- experimental_model
- Colony formation, proliferation and caspase assays with intracranial human meningioma implants in mice
- exposure
- Mebendazole alone and combined with radiation
- limitations
- A combination study in one meningioma line and one implanted model. The mechanism is inferred from immunohistochemistry rather than dissected.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Human cells and mouse
- plain_language
- Added to radiation it killed more tumour cells than radiation alone.
- primary_references
- [mbz-p30414098] Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma. (2018). https://pubmed.ncbi.nlm.nih.gov/30414098/ DOI: 10.1007/s11060-018-03009-7
- tissue_or_cell_type
- Malignant meningioma
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Colony formation, proliferation and caspase assays with intracranial human meningioma implants in mice · source_derived_draft · unverified_draft
### mbz-adds-to-radiation In meningioma cell lines the half-maximal inhibitory concentration for mebendazole was 0.26 to 0.42 micromolar, mebendazole alone induced cytotoxicity but the combination with radiation gave a greater reduction in colony formation and higher levels of cleaved caspase-3, and in mice implanted intracranially with human meningioma both mebendazole alone and the combination gave a survival benefit with increased apoptosis and decreased tumour cell and vascular proliferation. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Added to radiation it killed more tumour cells than radiation alone. organism: Human cells and mouse tissue_or_cell_type: Malignant meningioma experimental_model: Colony formation, proliferation and caspase assays with intracranial human meningioma implants in mice limitations: A combination study in one meningioma line and one implanted model. The mechanism is inferred from immunohistochemistry rather than dissected. exposure: Mebendazole alone and combined with radiation evidence_span: {"source_cache": "artifacts/mebendazole-research/30414098.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34445c01e56a2bfa33e4d1118f86c291fab041b15fa08da37592f4ec92d81400", "start_char": 0, "end_char": 1743, "text_sha256": "34445c01e56a2bfa33e4d1118f86c291fab041b15fa08da37592f4ec92d81400"} [mbz-p30414098] Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma. (2018). https://pubmed.ncbi.nlm.nih.gov/30414098/ DOI: 10.1007/s11060-018-03009-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.