Component
Cell survival after ionizing radiation
Cell survival after ionizing radiation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
DIM protected cultured cells and rodents against irradiation under the tested schedules; tested breast-cancer xenografts were not protected.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/24127581.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc", "start_char": 0, "end_char": 1379, "text_sha256": "6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc"}
- experimental_model
- Cell signaling and rodent radiation experiments
- exposure
- Submicromolar cell exposures and multidose rodent DIM schedules
- limitations
- No human radioprotection trial. Lack of protection in tested tumor xenografts cannot establish safety with all radiotherapy or cancer types.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- Cultured cells and irradiated rodents; breast-tumor xenografts separately
- plain_language
- Protection of one model does not establish protection or safety in every tissue.
- primary_references
- [dim-p24127581] DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. (2013). https://pubmed.ncbi.nlm.nih.gov/24127581/ DOI: 10.1073/pnas.1308206110
- tissue_or_cell_type
- ATM-mediated damage response
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 1442–1453
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cell signaling and rodent radiation experiments · source_derived_draft · unverified_draft
### dim-radiation-survival DIM protected cultured cells and rodents against irradiation under the tested schedules; tested breast-cancer xenografts were not protected. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Protection of one model does not establish protection or safety in every tissue. organism: Cultured cells and irradiated rodents; breast-tumor xenografts separately tissue_or_cell_type: ATM-mediated damage response experimental_model: Cell signaling and rodent radiation experiments limitations: No human radioprotection trial. Lack of protection in tested tumor xenografts cannot establish safety with all radiotherapy or cancer types. exposure: Submicromolar cell exposures and multidose rodent DIM schedules evidence_span: {"source_cache": "artifacts/dim-research/24127581.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc", "start_char": 0, "end_char": 1379, "text_sha256": "6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc"} [dim-p24127581] DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. (2013). https://pubmed.ncbi.nlm.nih.gov/24127581/ DOI: 10.1073/pnas.1308206110
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.