Component
Ovine cyclooxygenase-1
Sheep COX-1 used in the 2008 purified-enzyme experiments; distinct from human PTGS1.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Delta-tocopherol-13′-carboxychromanol competitively inhibited purified ovine COX-1 cyclooxygenase activity with a reported Ki of 3.9 µM, measured by initial oxygen consumption while varying arachidonic acid.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Purified-enzyme oxygen-electrode kinetics
- exposure
- 13′-COOH 0, 7.5, 15 or 25 µM; arachidonic acid 6–200 µM in Tris pH 8 with 1 µM hematin, phenol and EDTA.
- limitations
- Purified enzyme kinetics do not establish human anti-inflammatory benefit. Cyclooxygenase and peroxidase activities must not be conflated.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Ovis aries
- plain_language
- The long-chain delta-tocopherol metabolite interfered with this purified enzyme’s use of arachidonic acid.
- primary_references
- [jiang2008] Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. (2008). https://pubmed.ncbi.nlm.nih.gov/19074288/ DOI: 10.1073/pnas.0810962106
- tissue_or_cell_type
- Cell-free enzyme
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 855–866
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified-enzyme oxygen-electrode kinetics · source_derived_draft · unverified_draft
### e-sig-delta-acid-cox1 Delta-tocopherol-13′-carboxychromanol competitively inhibited purified ovine COX-1 cyclooxygenase activity with a reported Ki of 3.9 µM, measured by initial oxygen consumption while varying arachidonic acid. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The long-chain delta-tocopherol metabolite interfered with this purified enzyme’s use of arachidonic acid. organism: Ovis aries tissue_or_cell_type: Cell-free enzyme experimental_model: Purified-enzyme oxygen-electrode kinetics limitations: Purified enzyme kinetics do not establish human anti-inflammatory benefit. Cyclooxygenase and peroxidase activities must not be conflated. exposure: 13′-COOH 0, 7.5, 15 or 25 µM; arachidonic acid 6–200 µM in Tris pH 8 with 1 µM hematin, phenol and EDTA. cross_nutrient: false [jiang2008] Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. (2008). https://pubmed.ncbi.nlm.nih.gov/19074288/ DOI: 10.1073/pnas.0810962106
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.