Component
Polysomnographic total sleep time
Polysomnographic total sleep time. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Sleep amount and architecture were similar after pyridoxine and placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/12080281.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9", "start_char": 0, "end_char": 1222, "text_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9"}
- experimental_model
- Placebo-controlled evening pyridoxine experiment
- exposure
- 100 mg pyridoxine at 17:00; evening/night sampling
- limitations
- Acute exposure in healthy men. Null supplementation response does not negate the enzymatic requirement for PLP or settle effects in B6 deficiency.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Twelve healthy men
- plain_language
- A plausible precursor pathway did not guarantee an observable sleep improvement.
- primary_references
- [melatonin-p12080281] The effect of pyridoxine administration on melatonin secretion in normal men. (2002). https://pubmed.ncbi.nlm.nih.gov/12080281/
- tissue_or_cell_type
- Melatonin secretion, temperature and polysomnography
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 786–797
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo-controlled evening pyridoxine experiment · source_derived_draft · unverified_draft
### melatonin-b6-sleep-null Sleep amount and architecture were similar after pyridoxine and placebo. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A plausible precursor pathway did not guarantee an observable sleep improvement. organism: Twelve healthy men tissue_or_cell_type: Melatonin secretion, temperature and polysomnography experimental_model: Placebo-controlled evening pyridoxine experiment limitations: Acute exposure in healthy men. Null supplementation response does not negate the enzymatic requirement for PLP or settle effects in B6 deficiency. exposure: 100 mg pyridoxine at 17:00; evening/night sampling evidence_span: {"source_cache": "artifacts/melatonin-research/12080281.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9", "start_char": 0, "end_char": 1222, "text_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9"} [melatonin-p12080281] The effect of pyridoxine administration on melatonin secretion in normal men. (2002). https://pubmed.ncbi.nlm.nih.gov/12080281/
Complete structured claim and evidenceTotal sleep time increased by about 36 minutes compared with placebo in beta-blocker-treated patients.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/23024438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3", "start_char": 0, "end_char": 2402, "text_sha256": "0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3"}
- experimental_model
- Randomized double-blind placebo-controlled trial
- exposure
- 2.5 mg melatonin nightly for three weeks
- limitations
- Small selected group; does not prove every beta-blocker user is deficient or that all low-melatonin states respond identically.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Hypertensive patients taking atenolol or metoprolol; 15 analyzed
- plain_language
- This is a measured sleep outcome in a specific medication context.
- primary_references
- [melatonin-p23024438] Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23024438/ DOI: 10.5665/sleep.2122
- tissue_or_cell_type
- Polysomnographic sleep
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 981–992
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### melatonin-beta-blocker-sleep-duration Total sleep time increased by about 36 minutes compared with placebo in beta-blocker-treated patients. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This is a measured sleep outcome in a specific medication context. organism: Hypertensive patients taking atenolol or metoprolol; 15 analyzed tissue_or_cell_type: Polysomnographic sleep experimental_model: Randomized double-blind placebo-controlled trial limitations: Small selected group; does not prove every beta-blocker user is deficient or that all low-melatonin states respond identically. exposure: 2.5 mg melatonin nightly for three weeks evidence_span: {"source_cache": "artifacts/melatonin-research/23024438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3", "start_char": 0, "end_char": 2402, "text_sha256": "0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3"} [melatonin-p23024438] Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23024438/ DOI: 10.5665/sleep.2122
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.