Component
Propylcobalamin
Synthetic straight-chain C3 alkylcobalamin used as an experimental dealkylation probe; not a physiological dietary coenzyme.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Fibroblasts from three cblC patients had little or no conversion of cobalt-57-labeled propylcobalamin into adenosylcobalamin and methylcobalamin, whereas control skin fibroblasts converted the probe.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Abstract; indexed Methods: Assessment of dealkylation; Discussion
- experimental_model
- Human control and cblC patient fibroblast labeling
- exposure
- 0.125 nM cobalt-57 propylcobalamin for 48 hours
- limitations
- Propylcobalamin is a synthetic C3 probe; patients and genotypes differ and this comparison does not quantify every natural vitamer response.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- A synthetic B12 probe exposed the processing defect in patient cells.
- primary_references
- [hannibal-2009-cell-processing] Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product (2009). https://pubmed.ncbi.nlm.nih.gov/19447654/ DOI: 10.1016/j.ymgme.2009.04.005
- tissue_or_cell_type
- Skin fibroblasts
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 809–821
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human control and cblC patient fibroblast labeling · source_derived_draft · unverified_draft
### b12-cblc-propyl-probe Fibroblasts from three cblC patients had little or no conversion of cobalt-57-labeled propylcobalamin into adenosylcobalamin and methylcobalamin, whereas control skin fibroblasts converted the probe. Condition category: machinery_impairment nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A synthetic B12 probe exposed the processing defect in patient cells. organism: Homo sapiens tissue_or_cell_type: Skin fibroblasts experimental_model: Human control and cblC patient fibroblast labeling limitations: Propylcobalamin is a synthetic C3 probe; patients and genotypes differ and this comparison does not quantify every natural vitamer response. exposure: 0.125 nM cobalt-57 propylcobalamin for 48 hours cross_nutrient: false evidence_location: Abstract; indexed Methods: Assessment of dealkylation; Discussion [hannibal-2009-cell-processing] Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product (2009). https://pubmed.ncbi.nlm.nih.gov/19447654/ DOI: 10.1016/j.ymgme.2009.04.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.