Component
Probenecid
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Probenecid or ibuprofen at 1 mM strongly inhibited human SLC5A8 activity in the oocyte assay.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human transporter voltage-clamp experiments.
- limitations
- High bath concentrations do not prove clinically meaningful butyrate depletion or justify changing a medicine.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Drugs can block this transporter under experimental conditions.
- primary_references
- The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 118–124
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human transporter voltage-clamp experiments. · source_derived_draft · unverified_draft
## butyrate-smct1-drug-block Drugs can block this transporter under experimental conditions. Probenecid or ibuprofen at 1 mM strongly inhibited human SLC5A8 activity in the oocyte assay. Model: Human transporter voltage-clamp experiments. Limitations: High bath concentrations do not prove clinically meaningful butyrate depletion or justify changing a medicine. Evidence access: Primary abstract The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.