Component
Primidone
Primidone. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Primidone competitively inhibited biotin uptake in human intestinal brush-border vesicles (Ki 2.25 mmol/L), without inhibiting basolateral biotin transport.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/biotin-research/2911998.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "15113710724eaa76fd9bee5cdf7b031ce185b922c826e10d27aa42235a17aeeb", "start_char": 0, "end_char": 1045, "text_sha256": "15113710724eaa76fd9bee5cdf7b031ce185b922c826e10d27aa42235a17aeeb"}
- experimental_model
- Transport assays in purified human intestinal brush-border and basolateral membrane vesicles
- exposure
- Carbamazepine or primidone; millimolar inhibitor constants
- limitations
- These are membrane-assay concentrations. The study does not establish that prescribed doses cause deficiency in every patient.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Homo sapiens
- plain_language
- The drug competed with biotin at the gut-facing membrane in this experiment.
- primary_references
- [b7-p2911998] Biotin transport in the human intestine: inhibition by anticonvulsant drugs. (1989). https://pubmed.ncbi.nlm.nih.gov/2911998/ DOI: 10.1093/ajcn/49.1.127
- tissue_or_cell_type
- Intestinal membrane vesicles
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 286–297
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transport assays in purified human intestinal brush-border and basolateral membrane vesicles · source_derived_draft · unverified_draft
### b7-primidone-uptake Primidone competitively inhibited biotin uptake in human intestinal brush-border vesicles (Ki 2.25 mmol/L), without inhibiting basolateral biotin transport. Condition category: machinery_impairment nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The drug competed with biotin at the gut-facing membrane in this experiment. organism: Homo sapiens tissue_or_cell_type: Intestinal membrane vesicles experimental_model: Transport assays in purified human intestinal brush-border and basolateral membrane vesicles limitations: These are membrane-assay concentrations. The study does not establish that prescribed doses cause deficiency in every patient. exposure: Carbamazepine or primidone; millimolar inhibitor constants evidence_span: {"source_cache": "artifacts/biotin-research/2911998.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "15113710724eaa76fd9bee5cdf7b031ce185b922c826e10d27aa42235a17aeeb", "start_char": 0, "end_char": 1045, "text_sha256": "15113710724eaa76fd9bee5cdf7b031ce185b922c826e10d27aa42235a17aeeb"} [b7-p2911998] Biotin transport in the human intestine: inhibition by anticonvulsant drugs. (1989). https://pubmed.ncbi.nlm.nih.gov/2911998/ DOI: 10.1093/ajcn/49.1.127
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.