Component
Retinopathy of prematurity incidence
Retinopathy of prematurity incidence. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 1992 trial reported ROP in 13% of inositol-treated infants versus 26% of placebo recipients, and stage 4 ROP in 0% versus 9%.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/inositol-research/1560798.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6ece5de763b822dca6ca1a93b5f7a61a2d94be9af29755ffd9379f16a983027e", "start_char": 0, "end_char": 2123, "text_sha256": "6ece5de763b822dca6ca1a93b5f7a61a2d94be9af29755ffd9379f16a983027e"}
- experimental_model
- Randomized double-blind neonatal trial
- exposure
- Inositol 80 mg/kg/day for the first five days during parenteral nutrition
- limitations
- Early-era neonatal care and short exposure. The indexed abstract has inconsistent BPD count/percentage arithmetic; that endpoint is not numerically reproduced here. ROP findings are retained with the later adverse trial.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Homo sapiens
- plain_language
- An early neonatal trial reported fewer severe eye complications.
- primary_references
- [ino-p1560798] Inositol supplementation in premature infants with respiratory distress syndrome. (1992). https://pubmed.ncbi.nlm.nih.gov/1560798/ DOI: 10.1056/nejm199205073261901
- tissue_or_cell_type
- 221 infants at 24–32 weeks gestation with respiratory distress
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1432–1443
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind neonatal trial · source_derived_draft · unverified_draft
### ino-preterm-1992-rop The 1992 trial reported ROP in 13% of inositol-treated infants versus 26% of placebo recipients, and stage 4 ROP in 0% versus 9%. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: An early neonatal trial reported fewer severe eye complications. organism: Homo sapiens tissue_or_cell_type: 221 infants at 24–32 weeks gestation with respiratory distress experimental_model: Randomized double-blind neonatal trial limitations: Early-era neonatal care and short exposure. The indexed abstract has inconsistent BPD count/percentage arithmetic; that endpoint is not numerically reproduced here. ROP findings are retained with the later adverse trial. exposure: Inositol 80 mg/kg/day for the first five days during parenteral nutrition evidence_span: {"source_cache": "artifacts/inositol-research/1560798.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6ece5de763b822dca6ca1a93b5f7a61a2d94be9af29755ffd9379f16a983027e", "start_char": 0, "end_char": 2123, "text_sha256": "6ece5de763b822dca6ca1a93b5f7a61a2d94be9af29755ffd9379f16a983027e"} [ino-p1560798] Inositol supplementation in premature infants with respiratory distress syndrome. (1992). https://pubmed.ncbi.nlm.nih.gov/1560798/ DOI: 10.1056/nejm199205073261901
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.