Component
Mortality in experimentally infected preterm pigs
Mortality in experimentally infected preterm pigs. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Oral citrulline increased mortality in infected preterm pigs; intravenous exposure did not significantly change mortality.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/38825026.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a41a36f1d4539b1bb87cbfbd145f54655183855c1a4ad0061589bee0c13df062", "start_char": 0, "end_char": 1404, "text_sha256": "a41a36f1d4539b1bb87cbfbd145f54655183855c1a4ad0061589bee0c13df062"}
- experimental_model
- Controlled infection experiment with oral or intravenous supplementation
- exposure
- Citrulline 1 g/kg followed by Staphylococcus epidermidis inoculation; 14-hour monitoring
- limitations
- Preclinical high-exposure neonatal infection model; does not establish harm from usual adult supplementation or benefit in human sepsis.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Preterm pigs; related cord-blood experiments
- plain_language
- Correcting a presumed precursor shortage did not improve this infection model.
- primary_references
- [citrulline-p38825026] Citrulline supplementation exacerbates sepsis severity in infected preterm piglets via early induced immunosuppression. (2024). https://pubmed.ncbi.nlm.nih.gov/38825026/ DOI: 10.1016/j.jnutbio.2024.109674
- tissue_or_cell_type
- Bacterial load, inflammation and survival
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1256–1267
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled infection experiment with oral or intravenous supplementation · source_derived_draft · unverified_draft
### citrulline-preterm-sepsis-mortality Oral citrulline increased mortality in infected preterm pigs; intravenous exposure did not significantly change mortality. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Correcting a presumed precursor shortage did not improve this infection model. organism: Preterm pigs; related cord-blood experiments tissue_or_cell_type: Bacterial load, inflammation and survival experimental_model: Controlled infection experiment with oral or intravenous supplementation limitations: Preclinical high-exposure neonatal infection model; does not establish harm from usual adult supplementation or benefit in human sepsis. exposure: Citrulline 1 g/kg followed by Staphylococcus epidermidis inoculation; 14-hour monitoring evidence_span: {"source_cache": "artifacts/citrulline-research/38825026.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a41a36f1d4539b1bb87cbfbd145f54655183855c1a4ad0061589bee0c13df062", "start_char": 0, "end_char": 1404, "text_sha256": "a41a36f1d4539b1bb87cbfbd145f54655183855c1a4ad0061589bee0c13df062"} [citrulline-p38825026] Citrulline supplementation exacerbates sepsis severity in infected preterm piglets via early induced immunosuppression. (2024). https://pubmed.ncbi.nlm.nih.gov/38825026/ DOI: 10.1016/j.jnutbio.2024.109674
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.