Component
Human PLPBP Arg241Gln
R241Q disease-associated human protein.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified R241Q lacked detectable bound PLP, but a fourfold molar PLP excess produced a mixture including holo-protein.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Full text: biochemical properties and Figure 2B-D
- experimental_model
- Recombinant human PLPBP and HEK293 proteomics.
- exposure
- Purification followed by PLP addition.
- limitations
- Biochemical reconstitution does not establish clinical rescue.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- This variant binds poorly but is not absolutely incapable of binding.
- primary_references
- [fux2020] Biochemical and Proteomic Studies of Human Pyridoxal 5'-Phosphate-Binding Protein (PLPBP). (2020). https://pubmed.ncbi.nlm.nih.gov/31825581/ DOI: 10.1021/acschembio.9b00857
- tissue_or_cell_type
- Recombinant human protein
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 400–411
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant human PLPBP and HEK293 proteomics. · source_derived_draft · unverified_draft
### b6-transport-plpbp-r241q Purified R241Q lacked detectable bound PLP, but a fourfold molar PLP excess produced a mixture including holo-protein. Condition category: machinery_impairment nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This variant binds poorly but is not absolutely incapable of binding. organism: Homo sapiens tissue_or_cell_type: Recombinant human protein experimental_model: Recombinant human PLPBP and HEK293 proteomics. limitations: Biochemical reconstitution does not establish clinical rescue. exposure: Purification followed by PLP addition. evidence_location: Full text: biochemical properties and Figure 2B-D [fux2020] Biochemical and Proteomic Studies of Human Pyridoxal 5'-Phosphate-Binding Protein (PLPBP). (2020). https://pubmed.ncbi.nlm.nih.gov/31825581/ DOI: 10.1021/acschembio.9b00857
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.